孤束核内儿茶酚胺能投射神经元接受面口部躯体伤害性和内脏传入信息汇聚的研究

发布时间：2018-06-08 05:37

本文选题：孤束核 + 臂旁核　；参考：《第四军医大学》2005年硕士论文

【摘要】：孤束核(NTS)是位于延髓背内侧的纵行核团,是内脏传入的主要投射区。NTS内的神经元可经Ⅶ、Ⅸ、Ⅹ对颅神经接受头颈和胸腹腔大部分内脏的初级传入信息。NTS被划分为多个亚核,不同亚核的功能不尽相同。其吻侧1/3与味觉传入相关,中尾段的腹外侧和中间内侧亚核与呼吸相关,中尾段的背内侧、胶质、小细胞、内侧和连合亚核与胃肠道及心血管的调节有关。NTS已被广泛认为是中枢和外周自律活动调节的起点。除内脏初级传入外,NTS也接受由脊髓背角Ⅰ层神经元中继的躯体伤害性信息。还可经三叉神经的分支接受头面部躯体传入信息。临床研究发现高强度面口部穴位的电针对躯体深层组织的刺激可影响内脏活动,而刺激迷走神经则能抑制牙髓神经炎性痛引起的二腹肌反射。提示作为迷走神经的主要中枢投射区,NTS可能在躯体—内脏反射通路中发挥重要的作用。Imbe.H等以完全弗氏佐剂(CFA)刺激大鼠的咬肌后,观察到NTS中大量表达FOS蛋白,而将注射侧的迷走神经切断后,FOS蛋白的表达量显著降低,说明对面口部深层组织的炎性刺激可诱发NTS神经元的活动,而且此种效应与迷走神经传递的内脏信息密切相关。 NTS内含有多种神经活性物质。在其内侧、连合及中间内侧亚核中分
[Abstract]:Nucleus tractus solitarius (NTS) is a longitudinal nucleus in the dorsal medial medulla. The neurons in NTS are the main projection region of visceral afferent. The neurons in NTS can be divided into multiple subnuclei via the primary afferent information of the cranial nerves receiving the viscera of the head and neck and most of the viscera of the thorax and abdominal cavity. Different subnuclei have different functions. A third of the rostral side was associated with taste afferents, ventrolateral and medial subnuclei of the middle and caudal segments were associated with respiration, dorsomedial, glial and microcells in the middle caudal segment. Medial and synoptic subnuclei are associated with gastrointestinal and cardiovascular regulation. NTS has been widely regarded as the starting point for regulation of central and peripheral autonomic activity. In addition to visceral primary afferent NTS also received somatic nociceptive information relayed by spinal dorsal horn layer I neurons. It can also receive somatic afferent information from the head and face through branches of the trigeminal nerve. The clinical study found that the stimulation of high intensity facial acupoints on deep body tissue can affect visceral activity, while vagal stimulation can inhibit the diabs reflex caused by pulpitis neuralgia. These results suggest that NTS, the main central projection region of vagus nerve, may play an important role in somatic visceral reflex pathway. However, the expression of FOS protein decreased significantly after vagotomy on the injection side, indicating that inflammatory stimulation in the deep tissue of the opposite mouth could induce the activity of NTS neurons. This effect is closely related to the visceral information transmitted by the vagus nerve. NTS contains a variety of neuroactive substances. In the medial, commissural and medial subnuclei.
【学位授予单位】：第四军医大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R33

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