长爪沙鼠速发型高脂血症模型的建立及与动脉粥样硬化相关性分析

发布时间：2018-06-12 03:29

本文选题：高脂血症 + 长爪沙鼠　；参考：《大连医科大学》2005年硕士论文

【摘要】：目的:建立长爪沙鼠速发型高脂血症模型的方法,探讨其高脂血症的发生,发展及与动脉粥样硬化的相关性。方法:高胆固醇组用含 1%胆固醇高脂饲料分别饲养大、小鼠和沙鼠,检测其血清 TC,HDL-C,LDL-C,TG;高脂组沙鼠饲以 1%胆固醇+10%猪油+10%蛋黄粉的高脂饲料,检测血清 TC,HDL-C,LDL-C,TG,在 120 天时处死动物,作组织形态学观察。结果:高胆固醇组沙鼠的 TC,HDL-C,LDL-C 在第 1 周时明显的升高,并且平稳的保持到四周。而 TG 相对平稳,没有变化。而大鼠,小鼠的 TC,HDL-C,LDL-C, TG 没有变化。高脂组沙鼠的 TC,HDL-C,LDL-C 的值一直都明显高于对照组,以LDL-C 升高为主,且出现了严重的脂肪肝,肝硬化,脾脏肿大和主动脉根部粥样硬化。结论:通过饲喂高脂饲料可快速诱发长爪沙鼠形成高脂血症模型;加重高脂血症的程度能导致长爪沙鼠形成动脉粥样硬化的病理改变。
[Abstract]:Objective: to establish the model of rapid hyperlipidemia in gerbils with long claws and to explore the occurrence and development of hyperlipidemia and the relationship between hyperlipidemia and atherosclerosis. Methods: the rats in high cholesterol group were fed with 1% cholesterol and high fat diet respectively. Mice and gerbils were tested for serum TCU HDL-C LDL-CG, high fat diet fed with 1% cholesterol 10% lard and 10% egg yolk powder, serum TCU HDL-C LDL-CG was detected, and animals were killed at 120 days, and the mice were killed at 120 days after feeding with 1% cholesterol 10% lard and 10% egg yolk powder. Results: the LDL-C of HDL-C in high cholesterol group increased significantly at the 1st week and kept steadily for four weeks. And TG is relatively stable, no change. However, there was no change in LDL-C and TG in rats and mice. The level of LDL-C in the high fat group was significantly higher than that in the control group, and there were severe fatty liver and liver cirrhosis. Conclusion: hyperlipidemia model can be induced quickly by feeding high fat diet, and the degree of hyperlipidemia can lead to the pathological changes of atherosclerosis in long claw gerbils.
【学位授予单位】：大连医科大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R-332;R363

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