结核分枝杆菌Rv2389c和Rv2450c基因的克隆表达及其生物学功能的初步研究
发布时间：2018-08-09 14:48
【摘要】：结核病(Tuberculosis，TB)一直是严重威胁人类健康的以呼吸系统感染为主的慢性传染性疾病，其病原菌是结核分枝杆菌(Mycobacteriumtuberculosis，MTB)。随着AIDS的蔓延，原来曾被人类控制并有望在发达国家消失的结核病，其发病率和死亡率在许多国家和地区出现上升的趋势。在过去的十年中，结核病成为人类死亡的重要原因。WHO报道，全球近三分之一的人已感染结核菌，每年有约八百万新结核病人出现，死亡的人数达两百万人，如果结核菌感染得不到有效控制的话，从2002年到2020年，，又将有10亿人感染结核菌。我国是世界上22个结核病高发国家之一，结核病人数居世界第二位，形势严峻。这可能是由于人类免疫缺陷病毒(HIV)在全世界范围的传播，引起艾滋病的广泛流行，机体免疫力下降甚至缺陷，进而导致结核病的流行。全球范围的移民和人口流动使结核菌传播范围进一步扩大。再加上90％结核菌感染者为隐匿感染，阻碍了结核病的防治。结核菌诊断的金标准是结核菌的培养，而其生长缓慢，如何使MTB快速生长成为研究热点之一。因此积极深入研究结核病的发病机制，找出更加有效的诊断、治疗和预防结核病的新技术、新方法和新疫苗具有深远的意义。
[Abstract]:Tuberculosis (TB) is a chronic infectious disease which is a serious threat to human health. The main pathogen of tuberculosis is Mycobacterium tuberculosis (MTB). With the spread of AIDS, tuberculosis, once controlled by human beings and expected to disappear in developed countries, has an increasing trend of morbidity and mortality in many countries and regions. In the past decade, tuberculosis has become an important cause of human death. The WHO reports that nearly 1/3 people worldwide have been infected with TB, and about 8 million new TB patients appear each year, with 2 million deaths. If TB infection is not effectively controlled, another 1 billion people will be infected between 2002 and 2020. China is one of the 22 countries with high incidence of tuberculosis. This may be due to the spread of human immunodeficiency virus (HIV) in the world, causing the widespread spread of AIDS, the decline of immunity and even the deficiency of the body, which leads to the prevalence of tuberculosis. Worldwide migration and population mobility have further expanded the spread of tuberculous bacteria. In addition, 90% of TB infection is concealed infection, which hinders the prevention and treatment of tuberculosis. The gold standard for the diagnosis of tuberculous bacteria is the culture of tuberculous bacteria, but its growth is slow. How to make the rapid growth of MTB become one of the research hotspots. Therefore, it is of great significance to study the pathogenesis of tuberculosis, find out more effective diagnosis, treatment and prevention of tuberculosis new technology, new methods and new vaccines.
【学位授予单位】：第四军医大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R346
本文编号：2174426
[Abstract]:Tuberculosis (TB) is a chronic infectious disease which is a serious threat to human health. The main pathogen of tuberculosis is Mycobacterium tuberculosis (MTB). With the spread of AIDS, tuberculosis, once controlled by human beings and expected to disappear in developed countries, has an increasing trend of morbidity and mortality in many countries and regions. In the past decade, tuberculosis has become an important cause of human death. The WHO reports that nearly 1/3 people worldwide have been infected with TB, and about 8 million new TB patients appear each year, with 2 million deaths. If TB infection is not effectively controlled, another 1 billion people will be infected between 2002 and 2020. China is one of the 22 countries with high incidence of tuberculosis. This may be due to the spread of human immunodeficiency virus (HIV) in the world, causing the widespread spread of AIDS, the decline of immunity and even the deficiency of the body, which leads to the prevalence of tuberculosis. Worldwide migration and population mobility have further expanded the spread of tuberculous bacteria. In addition, 90% of TB infection is concealed infection, which hinders the prevention and treatment of tuberculosis. The gold standard for the diagnosis of tuberculous bacteria is the culture of tuberculous bacteria, but its growth is slow. How to make the rapid growth of MTB become one of the research hotspots. Therefore, it is of great significance to study the pathogenesis of tuberculosis, find out more effective diagnosis, treatment and prevention of tuberculosis new technology, new methods and new vaccines.
【学位授予单位】：第四军医大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R346
【引证文献】
相关硕士学位论文 前1条
1 周珊;HBHA在MTB感染AECⅡ过程中的作用研究[D];第四军医大学;2010年
本文编号：2174426
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