高脂饲料对长爪沙鼠血脂和血清电解质的影响

发布时间：2018-08-12 15:07

【摘要】：目的观察高脂饲料对长爪沙鼠血清脂质4项和血清电解质K+、Na+、Cl-、Ca2+、Mg2+含量的影响。方法选取雄性长爪沙鼠40只,随机分为两组,分别给予普通饲料和高脂饲料(含1%胆固醇、10%猪油)。喂养12周后颌下静脉丛采血,用日立7180型全自动生化分析仪检测血清TC、TG、HDL-C、LDL-C及Ca2+、Mg2+含量,用美国Easy Lyte Plus型电解质分析仪检测血清K+、Na+、Cl-含量。结果与正常饲料组相比,高脂饲料喂养后沙鼠血清TC、TG、HDL-C、LDL-C含量显著升高(P0.01),以TC、LDL-C水平升高最为明显。沙鼠血清电解质K+、Mg2+含量在不同饲料组差异有显著性(P0.01或P0.05),而Na+、Cl-、Ca2+含量在不同饲料喂养组的差异不显著(P0.05)。结论高脂饲料能明显升高长爪沙鼠血清脂质4项,并改变其血清电解质K+、Mg2+水平。
[Abstract]:Objective to observe the effects of high fat diet on the contents of serum lipids and serum electrolytes K _ (Na) C _ (1) Cl ~ (2 +) Ca ~ (2 +) ~ (2 +) mg _ (2) in gerbils. Methods Forty male gerbils were randomly divided into two groups: normal diet and high fat diet (containing 1% cholesterol and 10% lard). After 12 weeks of feeding, the blood samples were collected from the submaxillary venous plexus. The serum TCG-TGG LDL-C and Ca2 mg _ 2 were measured by Hitachi 7180 automatic biochemical analyzer, and the serum K _ (+) Na _ (+) Cl- content was detected by Easy Lyte Plus electrolyte analyzer. Results compared with the normal diet group, the content of HDL-CU LDL-C in serum of gerbils fed with high fat diet was significantly increased (P0.01), especially the level of TCU LDL-C. There was significant difference in serum electrolyte K and mg 2 content between different feed groups (P0.01 or P0.05), but there was no significant difference between different feed feeding groups (P0.05). Conclusion High fat diet can significantly increase serum lipid level and change serum electrolyte K ~ (2 +) mg _ (2) level in gerbils.
【作者单位】：广东医学院基础医学院;广东医学院第二临床医学院;东莞市慢性病防治院检验科;
【基金】：广东省高等学校人才引进专项资金项目(粤财教[2013]246号) 广东省自然科学基金项目(编号:S2011010002984)
【分类号】：R-332

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