联合应用β内酰胺类可增强万古霉素对耐甲氧西林金黄色葡萄球菌血流感染的抗菌活性
发布时间：2018-08-16 14:37
【摘要】：正万古霉素广泛用于治疗耐甲氧西林金黄色葡萄球菌(MRSA)血流感染。近期的研究发现,β内酰胺类联合万古霉素对MRSA有协同作用。作者比较采用万古霉素联合β内酰胺类与万古霉素单独用对MRSA血流感染患者的细菌清除情况。MRSA细菌清除定义为治疗后(≥24 h)血培养转为阴性。本研究共纳入80例患者,其中万古霉素单药组30例,联合用药组50例,联合应用的β内酰胺类药物包括哌拉西林-他唑巴坦(68%)、头孢克肟(8%)、头孢曲松(6%)
[Abstract]:Vancomycin is widely used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections. Recent studies have shown that beta-lactams combined with vancomycin have synergistic effects on MRSA. The authors compared the bacterial clearance of patients with MRSA bloodstream infections by vancomycin combined with beta-lactams and vancomycin alone. In addition to the definition of negative blood culture (> 24 h) after treatment, 80 patients were enrolled in this study, including 30 cases in the vancomycin monotherapy group and 50 cases in the combined therapy group. The combined use of beta-lactams included piperacillin-tazobactam (68%), cefixime (8%) and ceftriaxone (6%).
【分类号】：R378
本文编号：2186279
[Abstract]:Vancomycin is widely used in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections. Recent studies have shown that beta-lactams combined with vancomycin have synergistic effects on MRSA. The authors compared the bacterial clearance of patients with MRSA bloodstream infections by vancomycin combined with beta-lactams and vancomycin alone. In addition to the definition of negative blood culture (> 24 h) after treatment, 80 patients were enrolled in this study, including 30 cases in the vancomycin monotherapy group and 50 cases in the combined therapy group. The combined use of beta-lactams included piperacillin-tazobactam (68%), cefixime (8%) and ceftriaxone (6%).
【分类号】：R378
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