新型佐剂CpG ODN的研究进展

发布时间：2018-08-18 15:53

【摘要】：目的:对CpG ODN对免疫系统的作用、作为疫苗佐剂的有效性和安全性研究进展进行综述,为CpG ODN作为新型佐剂的研究和应用提供参考。方法:通过查阅近年来与CpG ODN免疫刺激活性、疫苗佐剂作用和安全性研究相关的国内外文献,进行归纳总结。结果:CpG ODN具有强免疫刺激作用,能促进DC、B细胞、NK、巨噬细胞等的增殖或活化,具有促进Th1型免疫应答的特点,CpG ODN的免疫刺激作用与激活TLR9有关。CpG ODN,尤其是B型CpG ODN,可作为佐剂增强针对感染性疾病的预防性疫苗和针对感染性疾病或肿瘤的治疗性疫苗的免疫效应。现有资料显示CpG ODN在一定的剂量范围内具有较好的安全性,在引起注射部位反应和过敏反应等方面,CpG ODN的安全性优于传统佐剂,但较高剂量下会引起一些其他方面的毒性作用。对CpG ODN结构及其传递系统的研究和改进是提高其临床应用有效性和安全性的重要手段。结论:CpG ODN具有强大的促进免疫应答的作用,是具有潜在应用前景的一种新型疫苗佐剂,目前CpG ODN的安全性尚未被完全阐明,有待于进行进一步的研究。
[Abstract]:Objective: to review the effects of CpG ODN on the immune system, the efficacy and safety of CpG ODN as a vaccine adjuvant, and to provide a reference for the study and application of CpG ODN as a new adjuvant. Methods: recent literatures about CpG ODN immunostimulatory activity, vaccine adjuvant and safety were reviewed and summarized. Results: CpG ODN had a strong immunostimulatory effect and could promote the proliferation or activation of NK and macrophages in DCB cells. The immunostimulatory effect of CpG ODN is related to the activation of TLR9. CpG ODNs, especially type B CpG ODNs, can be used as adjuvants to enhance the preventive vaccine against infectious diseases and the treatment of infectious diseases or tumors. Immune effects of therapeutic vaccines. The available data show that CpG ODN has better safety in a certain dose range, the safety of CpG ODN is superior to that of traditional adjuvant in causing injection site reaction and allergic reaction, but higher dose can cause some other toxic effects. The research and improvement of CpG ODN structure and its delivery system is an important means to improve the effectiveness and safety of its clinical application. Conclusion: CpG ODN is a novel vaccine adjuvant with potential application prospects, and the safety of CpG ODN has not been fully elucidated, which needs further study.
【作者单位】：中国食品药品检定研究院国家药物安全评价监测中心药物非临床安全评价研究北京市重点实验室;中国食品药品检定研究院;
【基金】：国家“重大新药创制”科技重大专项(2012ZX09302001,2012ZX09505001-004)
【分类号】：R392

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