低强度脉冲磁场生物效应机理研究

发布时间：2018-12-13 00:13

【摘要】：目前,磁场生物效应是生物医学工程学界的研究热点。在两次国家自然科学基金[①低强度脉冲电磁场治疗心血管疾病的机理研究,50077023(2000年),负责人:罗二平;②低强度脉冲电磁场治疗骨质疏松症的机理研究,50377044(2003年),负责人:罗二平]的资助下,对磁场生物效应进行了较为深入系统地研究。本文首先评述了磁场生物效应的研究进展。通过动物模型的建立和体外细胞的培养,进一步检测生理、生化、免疫、生物力学等指标,以心血管疾病和骨质疏松症为突破口,重点研究低强度脉冲磁场对机体的影响,探讨磁场生物效应的产生机理,以期为心血管疾病及骨质疏松症的预防和治疗提供新的思路和理论依据。主要工作概括如下: 1.基于相干电振荡理论、离子对膜的穿透理论和跨膜离子的回旋谐振理论等,对磁场非热生物效应机理进行了分析研究。阐释了磁场与生物系统之间相互作用的机理:①生物体对一定条件的磁场的响应是非线性的,并表现出频率特异性和功率特异性——“窗口效应”;②指出生物体对极低频(100 Hz)、低强度(100Gs)磁场非热效应的应答优于热效应,低强度脉冲磁场容易导致机体内非热生物累积效应的发生。 2.成功建立了高脂血症、动脉粥样硬化等心血管疾病动物模型和绝经后骨质疏松动物模型,定量分析了血液流变学、血脂、心功能、骨形态计量学、骨密度、生化、免疫以及生物力学等指标,结合大体解剖学和组织病理学分析,通过对实验整体方案的合理设计,体内与体外实验相结合,系统研究研究了低强度脉冲磁场对心血管系统和骨骼系统的影响,探讨了脉冲磁场生物效应的作用机理,为临床上心血管疾病和骨质疏松症的预防、治疗提供了新的思路和理论依据。 3.通过对脉冲磁场作用下血管受力机理的深入分析,首次提出了合理选择低
[Abstract]:At present, the biological effect of magnetic field is a hot topic in biomedical engineering. At the National Natural Science Foundation of China [1] study on the mechanism of low-intensity pulsed electromagnetic field in treating cardiovascular disease, 50077023 (2000), in charge of Luo Erping; (2) study on the mechanism of low intensity pulsed electromagnetic field in the treatment of osteoporosis, 50377044 (2003), sponsored by Luo Erping, a deep and systematic study on the biological effect of magnetic field. In this paper, the research progress of the biological effect of magnetic field is reviewed. Through the establishment of animal models and cell culture in vitro, the physiological, biochemical, immunological, biomechanical and other indicators were further examined. The impact of low intensity pulsed magnetic field on the body was studied with cardiovascular disease and osteoporosis as the breakthrough point. To explore the mechanism of the biological effect of magnetic field in order to provide new ideas and theoretical basis for the prevention and treatment of cardiovascular diseases and osteoporosis. The main work is summarized as follows: 1. Based on coherent electric oscillation theory, ion penetration theory and cyclotron resonance theory, the mechanism of nonthermal biological effect of magnetic field is studied. The mechanism of interaction between magnetic field and biological system is explained: (1) the response of organism to the magnetic field under certain conditions is nonlinear, and it shows frequency specificity and power specificity "window effect"; 2 it is pointed out that the response of organism to non-thermal effect of extremely low frequency (100 Hz),) low intensity (100Gs) magnetic field is superior to that of thermal effect, and low intensity pulsed magnetic field can easily lead to non-thermal bioaccumulation effect in organism. 2. The animal models of cardiovascular diseases such as hyperlipidemia, atherosclerosis and postmenopausal osteoporosis were successfully established. The quantitative analysis of hemorheology, blood lipids, cardiac function, bone morphometry, bone mineral density, biochemistry, Immune and biomechanical indicators, combined with gross anatomy and histopathological analysis, through the rational design of the overall experimental scheme, in vivo and in vitro experiments, The effects of low intensity pulsed magnetic field on cardiovascular system and bone system were studied systematically. The mechanism of biological effect of pulsed magnetic field was discussed, which could be used to prevent cardiovascular disease and osteoporosis in clinic. Treatment provides a new way of thinking and theoretical basis. 3. Based on the deep analysis of the stress mechanism of blood vessels under the action of pulsed magnetic field, the reasonable selection of low pressure is proposed for the first time.
【学位授予单位】：西安电子科技大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R35

【引证文献】