磁分离酶联免疫测定系统在细胞因子检测中的应用

发布时间：2018-12-17 09:28

【摘要】：细胞因子(Cytokine,CK)是指主要由免疫细胞分泌的、能调节细胞功能的小分子多肽或糖蛋白。数十年来,细胞因子的研究十分迅猛,现已发现200余种细胞因子。细胞因子具有广泛的生物学活性,比如参与固有性免疫及适应性免疫应答中细胞的动员产生,维持免疫细胞的生长、发育及分化,细胞的活化凋亡,刺激造血,体内免疫平衡的维持及监视等。在免疫应答过程中,细胞因子以极低浓度发挥着调节细胞间相互作用、细胞的生长和分化的重要作用。细胞因子主要由参与应答外来刺激的免疫细胞产生,偶尔为组成性分泌。细胞因子与细胞表面相应的细胞因子受体结合发挥作用。细胞因子可根据结构和功能分为几个不同的种类,如白细胞介素、干扰素、肿瘤坏死因子超家族、集落刺激因子、趋化性细胞因子家族、转化生长因子β家族等。目前已证实,以往所发现的不同病原生物感染所引起的细胞或体液免疫应答实际上主要是由Th1和Th2通过分泌不同的细胞
[Abstract]:Cytokines (Cytokine,CK) are small peptides or glycoproteins mainly secreted by immune cells that regulate cell function. In recent decades, the study of cytokines has been very rapid, and more than 200 cytokines have been found. Cytokines have a wide range of biological activities, such as the mobilization of cells involved in innate and adaptive immune responses, the maintenance of the growth, development and differentiation of immune cells, the activation and apoptosis of cells, and the stimulation of hematopoiesis. Maintenance and monitoring of immune balance in the body. Cytokines play an important role in regulating intercellular interaction, cell growth and differentiation during immune response. Cytokines are mainly produced by immune cells that respond to foreign stimuli and are occasionally secreted constitutively. Cytokines bind to the corresponding cytokine receptors on the cell surface. Cytokines can be divided into several kinds according to their structure and function, such as interleukin, interferon, tumor necrosis factor superfamily, colony stimulating factor, chemotactic cytokine family, transforming growth factor 尾 family and so on. It has been confirmed that the cellular or humoral immune responses caused by previously discovered infections of different pathogenic organisms are actually mainly secreted by Th1 and Th2 through different cells.
【学位授予单位】：第四军医大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R392

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