内吗啡肽在炎性痛动物脊髓内镇痛作用的行为学观察
发布时间：2019-01-06 15:23
【摘要】：脊髓背角浅层,不仅是接受无髓和薄髓初级传入纤维传递的外周伤害性信息的初级门户,也是来自中枢内源性镇痛系统投射纤维传递的痛抑制信息的主要终止部位。阿片类物质在脊髓背角浅层具有调控外周伤害性信息向中枢传递的重要作用。脊髓背角浅层内有密集的内吗啡肽(EMs)样阳性纤维和终末,EMs是μ阿片受体(MOR)的内源性高选择性配体。EMs样阳性结构在脊髓背角内的分布与MOR的分布互相匹配。EMs分为EM-1和EM-2。在啮齿动物中,EM-1主要存在于脊髓以上的脑结构,而EM-2主要分布于脊髓水平。脊髓背角浅层的EM-2样阳性结构主要来源于初级传入纤维和终末。鞘内注射EMs比将EMs注射到脑室系统内能发挥更强烈的镇痛作用。电生理研究的结果显示鞘内注射EM-2能选择性地抑制由刺激C纤维所引起的痛反应。脊髓背根神经节(DRG)内有EM-2样阳性神经元胞体。EM-2与P物质(SP)在大量DRG神经元内共存。以上结果提示EMs在伤害性信息的调控中可能发挥了重要作用。为了进一步阐明其镇痛机制,本研究采用行为药理学方法观察了EMs
[Abstract]:The superficial layer of spinal dorsal horn is not only the primary portal of peripheral nociceptive information transmitted by unmyelinated and thin medullary primary afferent fibers, but also the main terminating point of pain suppression information transmitted by the projection fibers of central endogenous analgesic system. Opioids play an important role in regulating the transmission of peripheral nociceptive information to the central nervous system in the superficial layer of the dorsal horn of the spinal cord. There were dense endomorphine-like (EMs) positive fibers and terminals in the superficial layer of the dorsal horn of the spinal cord. EMs is the endogenous high selective ligand of 渭 opioid receptor (MOR). The distribution of EMs like positive structure in the dorsal horn of spinal cord matches the distribution of MOR. EMs is divided into EM-1 and EM-2.. In rodents, EM-1 mainly exists in the brain structure above the spinal cord, while EM-2 is mainly distributed at the spinal cord level. The EM-2-like positive structures in the superficial layer of the dorsal horn of the spinal cord are mainly derived from primary afferent fibers and terminals. Intrathecal injection of EMs has a stronger analgesic effect than intrathecal injection of EMs into the ventricular system. The results of electrophysiological studies showed that intrathecal injection of EM-2 could selectively inhibit the pain response induced by stimulation of C fibers. There were EM-2 like positive neurons in (DRG) of dorsal root ganglion of spinal cord. EM-2 and substance P (SP) co-existed in a large number of DRG neurons. These results suggest that EMs may play an important role in the regulation of nociceptive information. In order to further elucidate the analgesic mechanism, EMs was observed by behavioral pharmacology.
【学位授予单位】：第四军医大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R33
本文编号：2402971
[Abstract]:The superficial layer of spinal dorsal horn is not only the primary portal of peripheral nociceptive information transmitted by unmyelinated and thin medullary primary afferent fibers, but also the main terminating point of pain suppression information transmitted by the projection fibers of central endogenous analgesic system. Opioids play an important role in regulating the transmission of peripheral nociceptive information to the central nervous system in the superficial layer of the dorsal horn of the spinal cord. There were dense endomorphine-like (EMs) positive fibers and terminals in the superficial layer of the dorsal horn of the spinal cord. EMs is the endogenous high selective ligand of 渭 opioid receptor (MOR). The distribution of EMs like positive structure in the dorsal horn of spinal cord matches the distribution of MOR. EMs is divided into EM-1 and EM-2.. In rodents, EM-1 mainly exists in the brain structure above the spinal cord, while EM-2 is mainly distributed at the spinal cord level. The EM-2-like positive structures in the superficial layer of the dorsal horn of the spinal cord are mainly derived from primary afferent fibers and terminals. Intrathecal injection of EMs has a stronger analgesic effect than intrathecal injection of EMs into the ventricular system. The results of electrophysiological studies showed that intrathecal injection of EM-2 could selectively inhibit the pain response induced by stimulation of C fibers. There were EM-2 like positive neurons in (DRG) of dorsal root ganglion of spinal cord. EM-2 and substance P (SP) co-existed in a large number of DRG neurons. These results suggest that EMs may play an important role in the regulation of nociceptive information. In order to further elucidate the analgesic mechanism, EMs was observed by behavioral pharmacology.
【学位授予单位】：第四军医大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R33
【参考文献】
相关期刊论文 前1条
1 孙瑞卿,王韵,赵承水,张肇康,韩济生;孤啡肽和内吗啡肽在神经源性痛模型大鼠疼痛相关脑区的改变[J];北京大学学报(医学版);2002年01期
，本文编号：2402971
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