汉坦病毒受体的筛选及鉴定

发布时间：2019-03-07 11:50

【摘要】：汉坦病毒属布尼亚病毒科,是一种有囊膜的单股负链RNA病毒,基因组分为大(L)、中(M)、小(S)3个节段,分别编码病毒的RNA依赖的RNA聚合酶、囊膜糖蛋白(G1和G2)以及核蛋白(NP)。糖蛋白G1和G2构成了病毒吸附蛋白(VAP)。汉坦病毒主要引起两种急性传染性疾病:一种是以发热、出血、急性肾功能损害和免疫功能紊乱为突出表现的肾综合征出血热(HFRS),另一种是以肺浸润及肺间质水肿,迅速发展为呼吸窘迫、衰竭为特征的汉坦病毒肺综合征(HPS)。我国是世界上HFRS疫情最为严重的国家,年发病人数为5-10万人,临床病情严重,病死率较高。目前,针对汉坦病毒引起的疾病尚无特异性治疗药物,其发病机理尚未最后阐明。病毒与细胞表面相应受体的结合是病毒感染复制过程中的始动环节,是决定病毒的宿主特异性、组织嗜性及致病性的主要因素之一。因此,汉坦病毒受体的研究有助于阐明其致病机制,为抗病毒治疗和疫苗的研制提供新的方法。目前汉坦病毒受体的研究已取得长足进展。国外研究表明,β_3整合
[Abstract]:Hantavirus belongs to Bunia viridae. It is a single-stranded negative-stranded RNA virus with envelope. The genome is divided into three segments of (M), and small (S) in large (L), which encodes RNA-dependent RNA polymerase of the virus, respectively. Envelope glycoprotein (G1 and G2) and nuclear protein (NP). Glycoprotein G1 and G2 constitute a viral adsorptive protein (VAP). Hantavirus mainly causes two kinds of acute infectious diseases: one is characterized by fever, hemorrhage, acute renal dysfunction and immune dysfunction, and the other is pulmonary infiltration and pulmonary interstitial edema, the other is hemorrhagic fever with renal syndrome (HFRS) (HFRS), which is characterized by fever, hemorrhage, acute renal dysfunction and immune dysfunction. Rapid development of Hantavirus lung syndrome (HPS). Characterized by respiratory distress and failure China is the country with the most serious HFRS epidemic in the world, the annual number of cases is 5-100000, the clinical condition is serious, and the fatality rate is high. At present, there are no specific therapeutic drugs for Hantavirus-induced diseases, and the pathogenesis of Hantavirus has not been clarified. The binding of virus to the corresponding receptors on the cell surface is one of the main factors that determine the host specificity, tissue tropism and pathogenicity of the virus, which is the initial link in the replication process of virus infection. Therefore, the study of Hantavirus receptor may help to clarify the pathogenesis of Hantavirus and provide a new method for antiviral therapy and vaccine development. At present, the research of Hantavirus receptor has made great progress. Foreign studies have shown that 尾 _ 3 integration
【学位授予单位】：第四军医大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R373

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