DC-SIGN介导HCV入胞作用的研究

发布时间：2019-06-25 08:38

【摘要】：丙型病毒性肝炎(简称丙肝)是由丙型肝炎病毒(hepatitis C virus，HCV)引起的传染病，人群普遍易感，已成为困扰全球人口健康的一大问题。目前，全球HCV感染者超过1.7亿，是引起慢性肝炎和肝硬化的主要原因。HCV的一个重要特征就是其极高的慢性化比例，尽管在HCV急性感染的过程中机体有可能清除病毒并获得终身免疫，但是80％以上的丙肝急性感染患者将发展成慢性丙型肝炎。目前为止丙肝尚无切实有效的预防和治疗方法。丙型肝炎病毒(HCV)属黄病毒科，为单股、正链、RNA包膜病毒，含大约9600个核苷酸。HCV基因组由位于5′端和3′端的两个非编码区和一个大的开放读码框(Open reading frame，ORF)组成。ORF编码一个约含有3000个氨基酸的前体蛋白，在病毒和宿主细胞的水解酶作用下，形成10个病毒蛋白，5′端为结构蛋白，依次为核心蛋白(C)、包膜蛋白(E1及E2)，3′端为非结构蛋白，，依次为P7、NS2、NS3、NS4A、NS4B、NS5A、NS5B。目前，有效的体外实验模型的缺乏限制了对HCV发病机理的研究。对HCV感染的早期过程，如病毒如何结合靶细胞上的受体最终进入细胞，病毒如何逃避机体的免疫攻击等，仍不很清楚。充分地了解HCV的受体及辅受体，对控制HCV的感染和传播至关重要。HCV的包膜糖蛋白E1／E2
[Abstract]:Viral hepatitis C (hepatitis C) is an infectious disease caused by hepatitis C virus (hepatitis C virus,HCV). It is generally susceptible to the population and has become a major problem that puzzles the health of the global population. At present, more than 170 million people with HCV infection in the world are the main causes of chronic hepatitis and liver cirrhosis. an important feature of HCV is its very high proportion of slowness. Although it is possible for the body to clear the virus and obtain lifelong immunization in the process of HCV acute infection, more than 80% of patients with acute hepatitis C infection will develop chronic hepatitis C. So far, there is no effective prevention and treatment of hepatitis C. Hepatitis C virus (HCV), a single strand, positive chain and RNA envelope virus, contains about 9600 nucleotides. HCV genome consists of two non-coding regions at 5 'and 3' ends and a large open reading frame (Open reading frame,ORF. ORF encodes a precursor protein containing about 3000 amino acids, which forms 10 viral proteins under the action of the virus and the hydrolase of the host cell, and the 5 'end of the virus is a structural protein. The HCV genome is composed of two non-coding regions at the 5' end and a large open reading frame HCV. ORF encodes a precursor protein containing about 3000 amino acids and forms 10 viral proteins under the action of the virus and the host cell hydrolase. The core protein (C), envelope protein (E1 and E2) was in turn, and the 3 'terminal was non-structural protein, followed by P7, NS2, NS3, NS4A, NS5A, NS5B, NS5B. At present, the lack of effective in vitro experimental model limits the study of the pathogenesis of HCV. The early process of HCV infection, such as how the virus binds the receptor on the target cell to enter the cell, how the virus evades the immune attack of the body, is still unclear. It is very important to fully understand the receptors and coreceptors of HCV in order to control the infection and transmission of HCV. E1/E2, an envelope glycoprotein of HCV, is very important to control the infection and transmission of HCV.
【学位授予单位】：第四军医大学
【学位级别】：硕士
【学位授予年份】：2006
【分类号】：R373

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