Role of FGF/FGFR signaling in skeletal development and homeo

发布时间：2021-12-31 17:23

　　Fibroblast growth factor（FGF）/fibroblast growth factor receptor（FGFR） signaling plays essential roles in bone development and diseases. Missense mutations in FGFs and FGFRs in humans can cause various congenital bone diseases, including chondrodysplasia syndromes, craniosynostosis syndromes and syndromes with dysregulated phosphate metabolism. FGF/FGFR signaling is also an important pathway involved in the maintenance of adult bone homeostasis. Multiple kinds of mouse models, mimicking human ske... 

【文章来源】：Bone Research. 2014,2(01)

【文章页数】：24 页

【文章目录】：
INTRODUCTION
ROLE OF FGFRS IN BONE GENETIC DISEASES AND HOMEOSTASIS
    FGFR1
    FGFR2
    FGFR3
    FGFR4
FGFS PARTICIPATE IN SKELETON DEVELOPMENT AND BONE METABOLISM
    FGF2
    FGF4
    FGF8
    FGF9
    FGF10
    FGF18
    FGF21
    FGF23
OTHER FGFS
CONCLUSIONS
Conflict of Interest


【参考文献】：
期刊论文
[1]Fgfr3基因374点突变致软骨发育不全小鼠模型的建立与分析[J]. 王建民,杜晓兰,李翠玲,尹良军,陈波,孙晶,苏楠,赵玲,宋瑞华,宋维威,陈林,邓初夏.  中华医学遗传学杂志. 2004(06)



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