化学发光法检测人免疫缺陷病毒抗体价值的Meta分析

发布时间：2018-03-17 04:14

本文选题：化学发光测定法　切入点：人免疫缺陷病毒　出处：《重庆医学》2017年36期 　论文类型：期刊论文

【摘要】：目的系统评价化学发光法检测人免疫缺陷病毒(HIV)抗体作为HIV初筛方法的价值。方法通过计算机检索和手工检索方法,收集万方、维普、中国知网(CNKI)、CBM、Pubmed、Web of Science等数据库发表的采用化学发光法检测HIV抗体的中文和英文研究,检索时限截止至2016年11月。由2位研究者按照纳入与排除标准独立筛选文献、提取资料和评价纳入研究的方法学质量后,应用Meta-disc1.4和Stata12.0软件进行Meta分析。结果共纳入8篇文献,共计26 168例受试者。Meta分析结果显示:化学发光法检测HIV抗体的合并敏感度为100%(95%CI:1.00~1.00),合并特异度为100%(95%CI:0.99~1.00),合并阳性似然比为237.79(95%CI:80.50~702.42),合并阴性似然比为0.00(95%CI:0.00~0.02),诊断比值比(DOR)为48 911.05(95%CI:8 257.50~289 711.20),曲线下面积AUC为0.999 4(SE=0.000 2)。结论化学发光法可作为HIV初筛方法在临床推广应用。
[Abstract]:Objective to evaluate the value of chemiluminescence assay for the detection of human immunodeficiency virus (HIV) antibody as a primary screening method for HIV. The Chinese and English studies on the detection of HIV antibodies by chemiluminescence were published in Chinese and English by using CBM Science and other databases. The search time was up to November 2016. The literature was independently screened by two researchers according to the inclusion and exclusion criteria. After extracting the data and evaluating the methodological quality of the study, Meta analysis was carried out by using Meta-disc1.4 and Stata12.0 software. The results were included in 8 articles. The results of Meta-analysis of 26 168 subjects showed that the combined sensitivity of chemiluminescence assay for detecting HIV antibody was 95 CI: 1.00, the combined specificity was 1000.991.00, the combined positive likelihood ratio was 237.79 ~ 95CII, the negative likelihood ratio was 0.0095 CI: 0.000. 02, the diagnostic ratio was 48. 911. 05% 95 CI 8 257.50289 711.20, and the negative likelihood ratio was 0. 0095 CI: 0. 002, and the diagnostic ratio was 48. 911. 05% 95 CI8 257.50289 711.20. The area under the curve of AUC is 0.999 4% SEP 0.00020.Conclusion chemiluminescence method can be used as HIV screening method in clinical application.
【作者单位】：新疆医科大学第一附属医院医学检验中心;
【分类号】：R446.6;R512.91

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