HBV感染型原发性肝癌患者肿瘤微环境中T细胞亚群及VEGF表达水平及临床意义

发布时间：2018-07-03 19:41

本文选题：乙型肝炎病毒 + 原发性肝癌　；参考：《中华医院感染学杂志》2017年07期

【摘要】：目的探讨HBV感染型原发性肝癌患者肿瘤微环境中CD_4~+、CD_8~+T细胞及血管内皮生长因子(VEGF)水平及临床意义,为临床治疗提供参考依据。方法前瞻性收集2014年1月-2016年1月收治的HBV感染型原发性肝癌患者57例为研究组,同期收集43例非HBV感染型原发性肝癌患者为对照组;比较两组患者临床指标。结果与对照组比较,研究组患者肿瘤组织微环境中CD_4~+T细胞显著增高、CD_8~+T细胞显著降低;调节性T细胞、VEGF阳性率、肿瘤组织中微血管密度值显著增加,差异均有统计学意义(P0.05);Pearson线性相关性分析显示,HBV DNA病毒载量与CD_4~+T细胞和调节性T细胞呈正比(P0.05);与VEGF阴性的患者相比,VEGF阳性HBV感染型原发性肝癌患者微血管密度值计数显著增加。结论 HBV感染型原发性肝癌患者调节性T细胞高表达,可能与HBV增殖有关,且VEGF阳性率增高,与肿瘤血管生成有关。
[Abstract]:Objective to investigate the level and clinical significance of CD4 ~ T cells and vascular endothelial growth factor (VEGF) in tumor microenvironment of patients with HBV infected primary liver cancer. Methods from January 2014 to January 2016, 57 patients with HBV infected primary liver cancer were collected as study group and 43 patients with non-HBV infected primary liver cancer as control group, and the clinical indexes of the two groups were compared. Results compared with the control group, the CD4 ~ T cells in the microenvironment of the patients in the study group were significantly increased and the CD8 ~ T cells were significantly decreased, the VEGF positive rate of regulatory T cells and the microvessel density in the tumor tissues were significantly increased. The difference was statistically significant (P0.05). Pearson linear correlation analysis showed that the viral load of HBV DNA was directly proportional to CD4 ~ T cells and regulatory T cells (P0.05), and the number of microvessel density (MVD) in patients with VEGF-positive HBV infected primary liver cancer was significantly higher than that in patients with VEGF-negative HBV infection type primary liver cancer (P0.05). Conclusion the high expression of regulatory T cells in patients with HBV infected primary liver cancer may be related to the proliferation of HBV and the increase of VEGF positive rate, which may be related to tumor angiogenesis.
【作者单位】：台州市第一人民医院病理科;台州市第一人民医院妇产科;
【基金】：浙江省医药卫生科技计划基金资助项目(2015KYB429)
【分类号】：R512.62;R735.7

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