血必净注射液联合亚胺培南西司他丁治疗腹腔重症感染的临床观察

发布时间：2018-08-20 12:58

【摘要】：目的:观察血必净注射液联合亚胺培南西司他丁治疗腹腔重症感染的临床疗效、安全性及对患者血浆内毒素、炎症因子的影响。方法:选取2013年4月-2016年4月在我院接受治疗的腹腔重症感染患者100例,按随机数字表法分为观察组和对照组,各50例。对照组患者给予注射用亚胺培南西司他丁钠0.5 g加入0.9%氯化钠注射液500 m L中,ivgtt(时间≥40 min),q12 h;观察组患者在对照组基础上间隔8 h给予血必净注射液100 m L加入0.9%氯化钠注射液500 m L中,ivgtt,bid。两组患者均治疗5~7d。比较两组患者治疗前后血浆内毒素和炎症因子[肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、IL-6/IL-10]水平及临床疗效,并记录不良反应发生情况。结果:治疗前,两组患者血浆内毒素和炎症因子水平比较,差异均无统计学意义(P0.05);治疗后,两组患者血浆内毒素和炎症因子水平均显著下降,且观察组水平显著低于对照组,差异均有统计学意义(P0.05)。观察组患者优良率为98.00%,显著高于对照组的78.00%,差异有统计学意义(P0.05)。两组患者均未见明显不良反应发生。结论:血必净注射液联合亚胺培南西司他丁治疗腹腔重症感染疗效显著,能有效控制患者内毒素以及炎症因子的释放,且安全性较高。
[Abstract]:OBJECTIVE: To observe the clinical efficacy and safety of Xuebijing injection combined with imipenem cilastatin in the treatment of severe abdominal infections and its effect on plasma endotoxin and inflammatory factors.Methods: 100 patients with severe abdominal infections who were treated in our hospital from April 2013 to April 2016 were divided into observation group and control group according to random number table method. The control group was given imipenem cilastatin sodium 0.5 g for injection into 0.9% sodium chloride injection 500 m L, IVGTT (time < 40 min), Q12 h; the observation group was given Xuebijing injection 100 m L added to 0.9% sodium chloride injection 500 m L, ivgtt, bid. The levels of plasma endotoxin and inflammatory factors [tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-6 (IL-6), and IL-10] were measured before and after treatment, and the adverse reactions were recorded. The levels of plasma endotoxin and inflammatory factors in the observation group were significantly lower than those in the control group, and the difference was statistically significant (P 0.05). The excellent and good rate of the observation group was 98.00%, which was significantly higher than that of the control group (78.00%). The difference was statistically significant (P 0.05). The combination of imipenem and cilastatin is effective in the treatment of severe abdominal infections and can effectively control the release of endotoxin and inflammatory factors.
【作者单位】：齐齐哈尔医学院附属第三医院检验科;齐齐哈尔医学院附属第三医院肿瘤一科;
【分类号】：R51

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