加味玉屏风饮治疗小儿肺脾气虚型反复呼吸道感染的临床观察

发布时间：2018-01-02 09:32

本文关键词：加味玉屏风饮治疗小儿肺脾气虚型反复呼吸道感染的临床观察　出处：《山西中医学院》2014年硕士论文　论文类型：学位论文

【摘要】：小儿反复呼吸道感染(RRTI)是儿科临床常见病、多发病之一,因其经常反复发作,缠绵难愈,严重影响小儿生活质量,是儿科临床面临的较为棘手的病证。中医药治疗手段温和、疗效确切,正在被越来越多的家长和患儿所接纳。目的:观察加味玉屏风饮对肺脾气虚型RRTI的临床治疗效果,并初步探讨其作用机制。方法:收集符合各项条件的肺脾气虚型小儿反复呼吸道感染患儿100例,所有病例均来自山西中医学院第二中医院儿科门诊,病例采集时间从2012年10月到2013年3月,患儿年龄分布在1~14岁之间。将100例患儿按照就诊顺序随机分成治疗组和对照组,每组50例。治疗组采取口服加味玉屏风饮(黄芪、党参、白术、防风、茯苓、炙甘草组成),日一剂,水煎服,早晚分服,3个月为一个疗程治疗,对照组单纯采用西安迪赛生物药业有限责任公司生产的转移因子口服液(每支10 ml),每次10 ml,每日1次,3个月为1个疗程。主要观察两组的临床疗效以及实验室检测T细胞亚群和免疫球蛋白前后指标变化。结果:100例患儿中96例患儿完成了整个研究过程,脱失、剔除病例4例。临床观察结果显示,治疗组的总有效率为95.83㳠,对照组总有效率为83.33㳠,其差异有统计学意义(P0.05)。用药后治疗组与对照组相比较,自汗、神疲乏力等中医临床症状非常显著改善(P0.01),咳嗽、纳差等中医临床症状明显改善(P0.05),其差异有统计学意义。两组患儿治疗后各项指标对照,治疗组IgA、Ig G均有非常明显改善,差异有统计学意义(P0.05)。两组治疗后对比,T细胞亚群指标变化有统计学意义(P0.05),且治疗组优于对照组。结论:加味玉屏风饮对肺脾气虚型小儿反复呼吸道感染治疗效果较好,能够有效控制患儿呼吸道感染疾病的反复发作,减少发病次数,延长发病间隔,降低发病等级,缩短疾病病程,并有效提高患儿体液免疫和细胞免疫水平,改善中医临床症状,且安全可靠,是治疗肺脾气虚型小儿反复呼吸道感染的有效方剂。
[Abstract]:Children with recurrent respiratory tract infection (RRTI) is a common disease in pediatrics, one of the frequent diseases, because of its recurrent attacks, lingering and difficult to heal, seriously affect the quality of life of children. It is a more intractable syndrome in pediatric clinic. Traditional Chinese medicine treatment is mild and effective. It is being accepted by more and more parents and children. Objective: to observe the clinical effect of Jiawei Yuping Fengyin on RRTI with deficiency of lung and spleen qi. Methods: 100 children with recurrent respiratory tract infection of lung and spleen qi deficiency type were collected. All cases were from the paediatric outpatient department of the second traditional Chinese Medicine Hospital of Shanxi College of traditional Chinese Medicine. Case collection time from October 2012 to March 2013, the age of the children between 1 and 14 years old. 100 children were randomly divided into treatment group and control group according to the order of visit. There were 50 cases in each group. The treatment group was treated with modified Yupingfeng decoction (Astragalus membranaceus, Codonopsis, Atractylodes macrocephala, Fangfeng, Poria cocos, Radix Glycyrrhiza officinalis, one dose per day, decoction of water, morning and evening, 3 months as a course of treatment). The control group was treated with the transfer factor oral liquid (10 ml / L, 10 ml / day) produced by Xi'an Desai Biopharmaceutical Co., Ltd. The clinical efficacy of the two groups and the changes of T cell subsets and immunoglobulin were observed before and after the laboratory examination. Results 96 out of 100 children were completed the whole study process. The clinical observation showed that the total effective rate of the treatment group was 95.83? , the total effective rate of control group was 83.33? The treatment group compared with the control group, self-sweating, fatigue and other TCM clinical symptoms were significantly improved P0.01, cough. The clinical symptoms of traditional Chinese medicine, such as anorexia, were obviously improved (P 0.05), and the difference was statistically significant. Compared with the control group, IgA Ig G in the treatment group was significantly improved. The difference was statistically significant (P 0.05). The changes of T cell subsets in the two groups were statistically significant (P 0.05). And the treatment group is better than the control group. Conclusion: modified Yuping Feng Yin has a better effect on recurrent respiratory tract infection in children with deficiency of lung and spleen qi. It can effectively control the recurrent attack of respiratory tract infection in children and reduce the incidence times. Prolonging the onset interval, reducing the grade of disease, shortening the course of disease, effectively improving the humoral and cellular immunity of children, improving the clinical symptoms of TCM, and safe and reliable. It is an effective prescription for recurrent respiratory tract infection in children with deficiency of lung and spleen qi.
【学位授予单位】：山西中医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R272

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