雄性激素在婴儿肛周脓肿发病中的作用及机制探讨

发布时间：2018-01-03 17:28

本文关键词：雄性激素在婴儿肛周脓肿发病中的作用及机制探讨　出处：《重庆医科大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的：研究肛周脓肿患儿血清总睾酮（T）、雄烯二酮（ADSD）、脱氢表雄酮（DHEA）水平与肛周脓肿（PA）发病的关系，并探讨婴儿肛周脓肿的发病机制。方法：前瞻性研究，随机选取重庆医科大学附属儿童医院胃肠、新生儿外科2009年12月-2012年8月住院的肛周脓肿男性患儿100例为实验组，并选取年龄3月以下的腹股沟疝（无嵌顿史）男性患儿11例为对照组。采用化学发光法测定其血清T、ADSD、DHEA浓度。运用SPSS19.0软件进行统计学处理，将实验组T、ADSD、DHEA值与对照组作相关性分析。结果：实验组患儿血清T水平8.01±4.29nmol/L较正常对照组的4.55±1.23nmol/L明显升高，差异有统计学意义(t=2.65，P0.05)；血清ADSD水平16.11±9.55nmol/L较正常对照组的6.78±2.30nmol/L明显升高，差异有统计学意义(t=3.21，P0.05)；血清DHEA水平1.70±1.21nmol/L较正常对照组的1.23±0.65nmol/L无明显升高，差异无统计学意义(t=1.24，P＞0.05)。结论：婴儿期雄性激素增高，，包括一过性雄性激素增高及从母体携带的雄性激素。可导致肛腺增生和分泌旺盛，粘液排泄不畅而堵塞腺导管。婴儿本身肛门直肠粘膜局部免疫结构未成熟，防御能力薄弱易受感染，感染通过肛腺（AG）逐渐蔓延至肛管直肠周围形成脓肿。故雄性激素增高可能与婴儿肛周脓肿的发病相关。
[Abstract]:Objective: to study the relationship between the levels of serum total testosterone (TX), androstenedione (ADSD), dehydroepiandrosterone (DHEAA) and the incidence of perianal abscess (PAA) in children with perianal abscess. To explore the pathogenesis of perianal abscess in infants. Methods: prospective study randomly selected 100 male children with perianal abscess hospitalized in the affiliated Children's Hospital of Chongqing Medical University from December 2009 to August 2012 as the experimental group. Eleven male children with inguinal hernia (no history of incarceration) under March were selected as the control group and their serum Tach-ADSD was determined by chemiluminescence method. The concentration of DHEA was analyzed by SPSS19.0 software, and the correlation analysis was made between the experimental group and the control group. Results: the serum T level in the experimental group was 8.01 卤4.29 nmol / L, which was significantly higher than that in the normal control group (4.55 卤1.23 nmol / L). The difference was statistically significant (P 0.05). The serum ADSD level was 16.11 卤9.55nmol / L and 6.78 卤2.30nmol / L in normal control group, and the difference was statistically significant. P0.05; The serum DHEA level was 1.70 卤1.21 nmol / L and 1.23 卤0.65 nmol / L in normal control group, and the difference was not statistically significant. P > 0.05. Conclusion: the increase of male hormone in infancy, including transient increase of androgen and androgen carried from mother, can lead to proliferation and exuberant secretion of anal gland. The mucus excretion is not smooth and the gland duct is blocked. The local immune structure of the baby's anorectal mucosa is immature and the defenses are weak and vulnerable to infection. The infection spread to the perianal abscess through the anus gland AGV, so the increase of androgen may be related to the development of perianal abscess in infants.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R725.7

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