地氟烷和七氟烷用于儿科麻醉术后恢复的Meta分析

发布时间：2018-01-15 13:42

  本文关键词：地氟烷和七氟烷用于儿科麻醉术后恢复的Meta分析　出处：《广西医科大学》2013年硕士论文　论文类型：学位论文

  更多相关文章： 地氟烷/地氟醚 七氟烷/七氟醚 儿科麻醉 meta分析

【摘要】：目的评价地氟烷和七氟烷用于儿科麻醉术后恢复的效果及不良反应。 方法电子检索PubMed, Cochrane图书馆,EMbase,中国生物医学文献数据库(CBM)和维普中文期刊数据库(VIP),文献检索时间均从建库至2012年2月,收集地氟烷和七氟烷用于儿科麻醉的随机对照试验(RCTs)。按Cochrane Handbook5.0.1提供的随机对照试验质量的评价标准评价纳入研究的方法学质量,使用RevMan5.0对纳入的患者资料进行Meta分析。剂量资料采用加权均数差值(WMD)进行分析,计算95%可信区间,计数资料采用比值比(0R)进行分析,计算95%可信区间。卡方检验进行异质性检验,固定效应模型采用Mantel-Haenszel法分析,随机效应模型采用Der SimonialLaird法分析,对于无法合并的资料进行描述性分析。 结果纳入9篇RCTs,包括840例患儿,其中地氟烷组414例,七氟烷组426例。Meta分析结果显示：在早期苏醒时间上地氟烷组快于七氟烷组,在术后恢复时间上两组差异没有统计学意义,在术后躁动的发生率上地氟烷组要高于七氟烷组,术后恶心呕吐(PONV)和严重疼痛(score≥6)两组差异没有统计学意义,眼心反射(OCR)两组差异亦没有统计学意义。 结论本研究结果表明地氟烷组麻醉术后早期苏醒快于七氟烷,苏醒期躁动发生率高于七氟烷组麻醉。在术后恢复、术后不良反应和眼心反射方面两者之间没有差异。
[Abstract]:Objective to evaluate the efficacy and adverse effects of desflurane and sevoflurane in the recovery of pediatric anesthesia. Methods PubMed, Cochrane Library, Chinese Biomedical Literature Database (CBM) and Weipu Chinese Journal Database (VIP) were searched electronically. The retrieval time of literature was from the construction of the database to February 2012. Collection of desflurane and sevoflurane for paediatric anesthesia in a randomized controlled trial (RCTs). To evaluate the quality of randomized controlled trials according to the evaluation criteria provided by Cochrane Handbook5.0.1. RevMan5.0 was used to analyze the patient data and the weighted mean value was used to analyze the dose data. The 95% confidence interval was calculated. Counting data were analyzed by ratio ratio of 0 R, 95% confidence interval was calculated. Chi-square test was used to test heterogeneity, and fixed effect model was analyzed by Mantel-Haenszel method. The stochastic effect model is analyzed by Der SimonialLaird method. Results 9 RCTs were included, including 840 children, including 414 in desflurane group. Meta-analysis of 426 cases in sevoflurane group showed that desflurane group was faster than sevoflurane group in early recovery time, and there was no significant difference in postoperative recovery time between the two groups. The incidence of postoperative restlessness was higher in the upper halothane group than in the sevoflurane group. There was no significant difference between the two groups in postoperative nausea and vomiting PONVV and severe pain score 鈮，

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