CD146在儿童与成人急性B淋巴细胞白血病细胞中表达及其意义

发布时间：2018-01-27 01:03

本文关键词： CD 急性B淋巴细胞白血病儿童成人免疫分型　出处：《中国实验血液学杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的:探讨CD146在儿童与成人急性B淋巴细胞白血病(B-ALL)细胞中表达的差异及其与其他抗原、临床、分子生物学及细胞遗传学特征的关系。方法:应用流式细胞仪检测CD146在儿童(44例)与成人(24例)BALL中的表达情况,并分析CD146异常高表达与性别、初诊时外周血血象、骨髓原始淋巴细胞与幼稚淋巴细胞比例等参数的关系,比较CD146与其他抗原之间的相关性,以及CD146异常高表达患者1个疗程的缓解率。结果:成人B-ALL中CD146异常高表达率为29.17%(7/24),儿童B-ALL中CD146异常高表达率为9.09%(4/44),在成人组显著高于儿童组(P0.05);在成人组中CD146与CD64(r=0.491,P0.05)和CD117(r=0.578,P0.05)呈正相关关系,在儿童组中CD146与CD71(r=0.419,P0.01)、CD58(r=0.301,P0.05)呈正相关关系;经1个疗程的正规化疗后,异常高表达CD146的成人组和儿童组的缓解率均低(P0.05)。结论:成人B-ALL患者的CD146表达率高于儿童B-ALL患者。CD146与预后较差的抗原呈正相关。CD146可能是一个预后不良的指标。
[Abstract]:Objective: to investigate the expression of CD146 in children and adults with acute B lymphoblastic leukemia (ALL) cells and its clinical significance with other antigens. Methods: flow cytometry was used to detect the expression of CD146 in 44 children (n = 44) and adults (n = 24). The relationship between the abnormal high expression of CD146 and sex, the blood picture of peripheral blood, the proportion of bone marrow primitive lymphocytes and immature lymphocytes were analyzed, and the correlation between CD146 and other antigens was compared. Results: the abnormal high expression rate of CD146 in adult B-ALL was 29.17 / 24). The abnormal high expression rate of CD146 in children with B-ALL was 9.09 / 44%, which was significantly higher in adults than in children (P 0.05). There was a positive correlation between CD146 and CD64 rhombus (P 0.05) and CD117R (0.578N P 0.05) in adult group. There was a positive correlation between CD146 and CD71rU 0.419 (P0.01P0.01) in the children group (P 0.05), and there was a positive correlation between CD146 and CD71P0.01P0.05in the children's group. After one course of regular chemotherapy. The remission rates of both adults and children with abnormal high expression of CD146 were low (P0.05). Conclusion: the expression rate of CD146 in adult B-ALL patients is higher than that in children B-ALL patients.
【作者单位】：郑州大学第一附属医院血液科;
【分类号】：R733.71
【正文快照】： 急性B淋巴细胞白血病(B-ALL)是一种原始和幼稚淋巴细胞克隆性为主的恶性疾病,是严重危害人类的一种常见的造血系统疾病。ALL在儿童急性白血病中占80%,而在成人中占25%,经治疗后儿童长期无病生存率达80%,而成人只有30%- 40%[11。在B-ALL中,成人与儿童抗原表达不完全相同[2],CD

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