CXCL13在结节性胃炎患儿胃黏膜中的表达及意义

发布时间：2018-01-27 08:25

本文关键词： 结节性胃炎幽门螺杆菌 CXCL CXCR 儿童　出处：《临床儿科杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的探讨超化因子CXCL13在结节性胃炎患儿胃黏膜中的表达及意义。方法选择临床诊断胃炎并行胃镜检查的216例患儿为研究对象,根据其内镜下是否存在结节性改变分为结节组和非结节组,评估研究对象胃黏膜组织病理学特点及CXCL13/CXCR5在胃黏膜中表达情况。结果结节组(n=102)与非结节组(n=114)胃黏膜中幽门螺杆菌(HP)感染率分别为70.59%和42.11%,中重度单核细胞浸润比例为74.51%和22.81%,中性粒细胞浸润比例为62.75%和33.33%,淋巴滤泡发生率为64.71%和20.18%,两组间差异均有统计学意义(P0.001)。所有HP感染者胃黏膜中均可见CXCL13、CXCR 5阳性染色。结节组胃黏膜中CXCL 13、CXCR 5阳性细胞百分比为(71.33±7.14)%和(73.54±7.92)%,高于非结节组的(45.88±5.92)%和(50.42±5.98)%,差异均有统计学意义(P0.001)。结论儿童结节性胃炎主要与HP感染有关,CXCL 13/CXCR 5在Hp感染患儿胃黏膜中表达增加,尤其在结节性胃炎中,可能参与了胃黏膜中淋巴样组织形成。
[Abstract]:Objective to investigate the expression and significance of superchemical factor CXCL13 in gastric mucosa of children with nodular gastritis. According to whether there were nodule changes under endoscope, they were divided into nodular group and non-nodular group. The histopathological characteristics of gastric mucosa and the expression of CXCL13/CXCR5 in gastric mucosa were evaluated. The infection rate of Helicobacter pylori in gastric mucosa was 70.59% and 42.11% respectively. The percentage of moderate and severe monocyte infiltration was 74.51% and 22.81, and the percentage of neutrophil infiltration was 62.75% and 33.33%. The incidence of lymphoid follicles was 64.71% and 20.18, and the difference between the two groups was statistically significant (P 0.001). CXCL13 was found in all HP infected gastric mucosa. The percentage of CXCL 13 CXCR5 positive cells in gastric mucosa of nodular group was 71.33 卤7.14% and 73.54 卤7.92% respectively. It was higher than that in non-nodular group (45.88 卤5.92% and 50.42 卤5.98%). Conclusion the expression of 13% CXCL13 / CXCR5 in gastric mucosa of children with HP infection was significantly increased in children with nodular gastritis. Especially in nodular gastritis, it may be involved in the formation of lymphoid tissue in gastric mucosa.
【作者单位】：南京医科大学附属儿童医院消化科;兰州大学第一医院儿科;南京医科大学附属无锡市儿童医院消化科;
【分类号】：R725.7
【正文快照】： (甘肃兰州730000);3.南京医科大学附属无锡市儿童医院消化科(江苏南京214000)结节性胃炎是一种特殊类型的慢性胃炎,主要与幽门螺杆菌(Helicobacter pylori,HP)感染有关,在儿童中更为常见[1-3]。有研究报道,结节性胃炎在组织病理学上以淋巴细胞为主的炎性细胞浸润及伴有生发中

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