赛若金联合无乳糖饮食对小儿轮状病毒感染性肠炎肠黏膜损伤及心肌酶谱的影响

发布时间：2018-01-27 15:22

本文关键词： 小儿轮状病毒感染性肠炎无乳糖饮食赛若金肠黏膜损伤心肌酶谱　出处：《中华医院感染学杂志》2017年18期 　论文类型：期刊论文

【摘要】：目的研究赛若金联合无乳糖饮食对小儿轮状病毒(RV)感染性肠炎肠黏膜损伤及心肌酶谱的影响。方法选取2015年10月-2016年10月在医院就诊的100例小儿轮状病毒感染性肠炎患儿,按照随机、对照、双盲试验原则分为观察组和对照组,各50例,对照组患儿采用注射用重组人干扰素α1b(赛若金)治疗,观察组患儿在此基础上联合无乳糖饮食治疗,通过临床总有效率、心肌酶谱、肠黏膜损伤相关指标、T淋巴细胞亚群等指标评估临床疗效。结果观察组患儿临床治疗有效率96.00%,明显高于对照组患儿84.00%(P0.05);治疗后观察组患儿门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(α-HBDH)值为(33.01±4.59)、(110.43±10.43)、(15.71±2.34)、(210.30±20.12)、(130.12±34.24)U/L,均低于对照组患儿(39.12±5.23)、(156.81±11.03)、(22.04±2.89)、(230.54±20.76)、(167.32±34.85)U/L,差异有统计学意义(P0.05);治疗后观察组患儿血清中晚期糖基化终末产物(AGEs)、内毒素(EXT)、二胺氧化酶(DAO)值分别为(165.41±34.02)ng/L、(0.31±0.12)EU/ml、(0.54±0.11)U/L,均低于对照组(243.12±34.78)ng/L、(0.76±0.20)EU/ml、(1.56±0.13)U/L,差异有统计学意义(P0.05);治疗后观察组患儿CD_3~+、CD_4~+、CD_4~+/CD_8~+值为(62.53±4.45)、(39.10±4.37)、(1.62±0.43),均高于对照组(57.01±4.79)、(35.22±4.87)、(1.44±0.34),观察组CD_8~+值(26.01±3.21),低于对照组(28.34±3.65),差异有统计学意义(P0.05)。结论对小儿轮状病毒感染性肠炎患者,赛若金联合无乳糖饮食,有利于快速减轻腹泻、腹痛症状,改善肠黏膜损伤,保护心肌功能,增强免疫功能,提高治疗效果,值得临床积极推广和应用。
[Abstract]:Objective to study the effect of sirogen plus lactose free diet on rotavirus RV in children. Methods 100 children with rotavirus infective enteritis from October 2015 to October 2016 were selected. According to the principle of randomized, controlled and double-blind trials, the children in the control group were divided into two groups: the observation group (n = 50) and the control group (n = 50). The children in the control group were treated with recombinant human interferon 伪 1b for injection. On this basis, the observation group combined with lactose free diet treatment, through the clinical total effective rate, myocardial enzyme spectrum, intestinal mucosal injury related indicators. Results the effective rate of clinical treatment in the observation group was 96.00, which was significantly higher than that in the control group (P 0.05). After treatment, aspartate aminotransferase (AST), creatine kinase (CK), creatine kinase isoenzyme (CK-MBN), lactate dehydrogenase (LDH) were detected in the observation group. The value of 伪 -hydroxybutyrate dehydrogenase (伪 -HBDH) was 33.01 卤4.59, 110.43 卤10.43, 15.71 卤2.34). 210.30 卤20.12 U / L 130.12 卤34.24 U / L were lower than those in control group (39.12 卤5.23 卤156.81 卤11.03). The difference was statistically significant (P 0.05). After treatment, the serum levels of advanced glycosylation end product (AGEsN), endotoxin extension (EXTX) and diamine oxidase (DAO) were 165.41 卤34.02 ng / L, respectively. 0.31 卤0.12 EU / ml 0.54 卤0.11 U / L was lower than that of control group (243.12 卤34.78 ng / L). 0.76 卤0.20 EU / ml = 1.56 卤0.13 U / L, the difference was statistically significant (P 0.05). After treatment, the value of CD3 / CD4 / CDS in the observation group was 62.53 卤4.45 + 39.10 卤4.37). 1.62 卤0.43, which was higher than that in the control group (57.01 卤4.79) and was 35.22 卤4.87 (1.44 卤0.34). The CD8 ~ value of the observation group was 26.01 卤3.21, which was lower than that of the control group (28.34 卤3.65). Conclusion for children with rotavirus infective enteritis, the combination of selokine and lactose free diet is beneficial to reduce diarrhea, abdominal pain and intestinal mucosal injury. Protection of myocardial function, enhancement of immune function and improvement of therapeutic effect are worth to be popularized and applied in clinic.
【作者单位】：河南大学淮河医院儿科;
【基金】：河南省教育厅自然科学基金资助项目(2009B360001)
【分类号】：R725.1
【正文快照】： 轮状病毒(RV)属于呼肠孤病毒科,是一种双链核糖核酸病毒,是引起婴幼儿腹泻的常见病原体[1]。轮状病毒感染性肠炎是由轮状病毒感染引起的病毒性胃肠炎,常见于婴幼儿,临床可表现为腹胀、腹痛、腹泻、低热等,严重影响患儿的身心健康。轮状病毒传播途径较多,如口、水源污染、呼吸

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