130例新生儿耳道分泌物主要病原菌分布与耐药性分析

发布时间：2018-01-31 00:33

本文关键词： 耳道分泌物细菌药物敏感性试验新生儿　出处：《第三军医大学学报》2017年15期 　论文类型：期刊论文

【摘要】：目的了解新生儿耳道分泌物病原菌的分布及耐药性,为临床诊治新生儿早发型感染及合理使用抗菌药物提供依据。方法对九龙坡区人民医院西城院区分娩的新生儿130例耳道分泌物进行病原菌的培养、分离、分析,并进行抗菌药物药敏试验检测和临床相关资料的分析。结果共分离出132株病原菌,前5位依次为大肠埃希菌、厌氧菌、粪肠球菌、无乳链球菌和白色假丝酵母菌。其中产ESBL的大肠埃希菌检出率为76.6%,大肠埃希菌对青霉素类抗菌药物、一代头孢具有较高的耐药率,对三代头孢耐药率较低,粪肠球菌和无乳链球菌对新生儿常用的青霉素类抗菌药物均保持较高的敏感性,白色假丝酵母菌对常见的抗真菌药物保持100%的敏感性。结论新生儿耳道分泌物中病原菌的分布及药敏试验对指导临床用药具有重要意义,可根据药敏试验结果合理使用抗菌药物。
[Abstract]:Objective to investigate the distribution and drug resistance of pathogenic bacteria in neonatal ear canal secretion. Methods 130 newborns born in Westtown Hospital of people's Hospital of Jiulongpo District were cultured and separated from 130 cases of newborn ear canal secretion. The results were as follows: (1) in order to provide basis for clinical diagnosis and treatment of neonatal early onset infection and rational use of antibiotics, 130 cases of neonatal ear canal secretions were cultured and separated. Results 132 strains of pathogenic bacteria were isolated, the first 5 were Escherichia coli, anaerobes and Enterococcus faecalis. The detection rate of Escherichia coli producing ESBL was 76. 6%. Escherichia coli had high resistance to penicillin antibiotics. The rate of resistance to the third generation of cephalosporins was low, and both Enterococcus faecalis and Streptococcus faecalis remained highly sensitive to penicillin antibiotics commonly used in newborns. Candida albicans remain 100% sensitive to common antifungal drugs. Conclusion the distribution of pathogenic bacteria in the secretion of newborn ear canal and drug sensitivity test are of great significance in guiding clinical drug use. Antimicrobial agents can be used reasonably according to the results of drug sensitivity test.
【作者单位】：重庆医药高等专科学校医学技术学院;九龙坡区人民医院西城分院内科;重庆医科大学附属第一医院检验科;
【分类号】：R722.13
【正文快照】： 坡区人民医院西城分院内科2;400016重庆,重庆医科大学附属第一医院检验科3)近年来,早发型新生儿感染已经成为新生儿尤其是低体质量新生儿死亡的重要原因之一(病死率为15%~30%),美国研究表明,约1‰~4‰的新生儿会发生早发型感染[1],及时诊断治疗是降低新生儿感染的关键。新生儿

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