葛根芩连汤直肠滴注联合推拿对湿热型腹泻小儿血清胃泌素、血浆胃动素及生长抑素水平的影响

发布时间：2018-02-01 03:16

本文关键词： 葛根芩连汤推拿腹泻胃泌素胃动素生长抑素湿热型　出处：《中国实验方剂学杂志》2017年23期 　论文类型：期刊论文

【摘要】：目的:观察葛根芩连汤直肠滴注联合推拿对湿热型腹泻小儿血清胃泌素、血浆胃动素及生长抑素水平的影响,并探讨其作用机制。方法:选取天津中医药大学第一附属医院2013年8月—2016年10月收治的100例腹泻患儿,按随机数字表法分为治疗组(50例)和对照组(50例)。在给予常规西医对症处理及支持疗法的基础上,对照组患儿予以推拿手法,治疗组在对照组的基础上加用葛根芩连汤进行直肠滴注给药,连续治疗3 d后,对两组患儿临床疗效,退热、止泻、腹痛消退时间、纠正脱水及恢复进食时间,中医证候积分,以及血清胃泌素(GAS),血浆胃动素(MOT)及生长抑素(SS)水平进行比较。结果:治疗组患儿总有效率为94.00%,对照组为82.00%,治疗组优于对照组(P0.05);经治疗,治疗组患儿在退热、止泻、腹痛、纠正脱水及恢复进食时间方面明显短于对照组(P0.05);治疗后与治疗前比较,两组中医证候积分均有明显改善(P0.05),治疗组中医证候积分明显低于对照组(P0.05);治疗前两组GAS,MOT,SS水平比较均无显著性差异,通过治疗,两组患者GAS,MOT水平均明显降低,SS水平明显升高,治疗组效果明显优于对照组(P0.05)。结论:葛根芩连汤直肠滴注联合推拿疗法可以明显缓解湿热型腹泻患儿临床症状,缩短治疗时间,通过有效协调胃肠道激素因子的平衡,改善胃肠道功能。
[Abstract]:Objective: to observe the effect of Gegen Qinlian decoction combined with massage on serum gastrin, plasma motilin and somatostatin levels in children with damp-heat diarrhea. Methods: 100 children with diarrhea were selected from the first affiliated Hospital of Tianjin University of traditional Chinese Medicine from August 2013 to October 2016. According to the random number table method, 50 cases were divided into treatment group (n = 50) and control group (n = 50). On the basis of routine western medicine treatment and support therapy, children in control group were treated with massage manipulation. Treatment group on the basis of the control group plus Gegen Qinlian decoction rectal drip, continuous treatment for 3 days, the two groups of children with clinical efficacy, antipyretic, diarrhea, abdominal pain subsided time. Correct dehydration and recovery time, TCM syndrome score, and serum gastrin GASs. Results: the total effective rate was 94.00 in the treatment group and 82.00% in the control group. The treatment group was superior to the control group (P 0.05). After treatment, the children in the treatment group in antipyretic, diarrhea, abdominal pain, correction of dehydration and food recovery time was significantly shorter than the control group P0.05; After treatment, compared with before treatment, the TCM syndromes integral of the two groups were significantly improved (P0.05N), and the TCM syndromes score of the treatment group was significantly lower than that of the control group (P0.05A). Before treatment, there was no significant difference in the level of GAS-MOTT between the two groups. Through the treatment, the level of GAS-MOT decreased significantly and the level of SS increased significantly in both groups. Conclusion: the rectal drip of Gegen Qinlian decoction combined with massage therapy can obviously alleviate the clinical symptoms of children with damp-heat diarrhea and shorten the treatment time. Through the effective coordination of the balance of gastrointestinal hormone factors, improve gastrointestinal function.
【作者单位】：天津中医药大学第一附属医院;
【基金】：天津市卫生和计划生育委员会中医中西医结合科研课题项目(2015100)
【分类号】：R272
【正文快照】： [网络出版地址]http://kns.cnki.net/kcms/detail/11.3495.R.20170906.1353.038.html[网络出版时间]2017-09-06 13:53小儿腹泻是婴幼儿临床常见的消化系统病种,临床常以大便频繁、便下稀薄、性状异常,或伴有未消化食物与黏液为主要特征[1]。小儿腹泻常发于夏秋两季,以3岁以下

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