超低出生体质量儿支气管肺发育不良的危险因素分析

发布时间：2018-02-06 07:56

本文关键词： 支气管肺发育不良肺疾病危险因素超低出生体质量儿　出处：《重庆医学》2017年26期 　论文类型：期刊论文

【摘要】：目的探讨超低出生体质量儿(ELBWI)支气管肺发育不良(BPD)的危险因素。方法对2010年1月至2015年12月入住山东大学附属省立医院及四川省人民医院新生儿重症监护病房(NICU),出生后24h内入院且存活至生后28d以上的151例ELBWI的临床资料进行调查分析。BPD组纳入任何氧依赖[吸入氧浓度(FiO2)21%]超过28d的新生儿,反之为非BPD组。比较两组间母亲孕期因素、新生儿因素及疾病治疗因素。结果 (1)151例ELBWI,发生BPD 57例,发生率为37.7%。(2)单因素分析结果显示,母亲是否患有绒毛膜羊膜炎、胎膜早破时间、出生体质量、胎龄、败血症、动脉导管未闭(PDA)、新生儿呼吸窘迫综合征(NRDS)、机械通气(MV)、MV时间、静脉营养时间、输血次数与ELBWI发生BPD相关,应用咖啡因是保护因素。(3)多元Logistic回归显示MV(OR=6.975,95%CI:1.464~33.219),母亲患有绒毛膜羊膜炎(OR=3.890,95%CI:1.656~9.140)是ELBWI发生BPD的独立危险因素。结论尽可能减少宫内感染及早产,产后合理进行呼吸支持,可有效降低ELBWI的BPD发生率。
[Abstract]:Objective to study the effect of ultra low birth weight infants (ELBWI) bronchopulmonary dysplasia (BPD) risk factors. Methods the affiliated Provincial Hospital of Shandong University and Sichuan Provincial People's Hospital from January 2010 to December 2015 in the neonatal intensive care unit (NICU), 24h after birth in hospital and the clinical data and survival after more than 28d in 151 cases of ELBWI were investigated and analyzed the.BPD group included any oxygen dependent [inhaled oxygen concentration (FiO2) of 21%] more than 28d of the newborn, whereas in non BPD group. Maternal factors were compared between the two groups, the treatment of neonatal factors and disease factors. Results (1) ELBWI in 151 cases, BPD 57 cases, the incidence rate was 37.7%. (2) single factor analysis results shows whether the mother suffered from chorioamnionitis, prom time, birth weight, gestational age, sepsis, patent ductus arteriosus (PDA), neonatal respiratory distress syndrome (NRDS), mechanical ventilation (MV), MV time, vein Nutrition time, the number of blood transfusion and the occurrence of ELBWI is related to BPD, the application of caffeine is a protective factor. (3) multivariate Logistic regression analysis showed that MV (OR=6.975,95%CI:1.464~33.219), the mother suffered from chorioamnionitis (OR=3.890,95%CI:1.656~9.140) is the independent risk factors of ELBWI BPD. Conclusion as far as possible to reduce intrauterine infection and preterm delivery, postpartum reasonable respiratory support, can be effective reduce the incidence of ELBWI BPD.

【作者单位】：四川省人民医院儿科;山东大学附属省立医院新生儿科;
【分类号】：R722.6

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