乌鲁木齐市手足口病的病原学特征分析

发布时间：2018-02-07 10:47

  本文关键词： 手足口病 RT-PCR 肠道病毒 病原体　出处：《现代预防医学》2017年23期 　论文类型：期刊论文

【摘要】：目的分析2010-2016年乌鲁木齐市手足口病的病原构成及病原学特征,为手足口病防治工作提供科学依据。方法收集乌鲁木齐市各级医疗机构手足口临床诊断病例标本,采用逆转录聚合酶链反应方法对肠道病毒核酸进行检测。结果 7年共采集4 791例手足口病病例标本,检出肠道病毒阳性3 875例,阳性率为80.88%,其中EV7l阳性1301例(27.16%),CoxA16阳性1 501例(31.33%),其他肠道病毒阳性1 068例(22.29%),EV7l和CoxA16混合感染阳性5例(0.10%);病例高峰期在5-7月(80.19%),发病人群集中在1~5岁(81.29%),标本中男女比例为1.43∶1,不同性别肠道病毒阳性检出率差异无统计学意义;7年间手足口病病原构成比差异有统计学意义(X~2=132.82,P0.001)。结论 2010-2016年乌鲁木齐市手足口病病原以EV7l和CoxA16为主,多型别共存,并交替流行,加强手足口病病原监测工作,尤其对其他肠道病毒的分型检测,为手足口病防治提供实验室依据。
[Abstract]:Objective to analyze the pathogenic composition and etiological characteristics of hand, foot and mouth disease in Urumqi from 2010 to 2016, and to provide scientific basis for the prevention and treatment of hand foot and mouth disease. Methods the clinical diagnosis cases of hand, foot and mouth in various medical institutions in Urumqi were collected. Results 4791 samples of hand, foot and mouth disease were collected in 7 years, and 3 875 positive cases of enterovirus were detected by reverse transcriptase polymerase chain reaction (RT PCR). The positive rate was 80.88, of which 1 501 cases were positive for EV7l, 1 501 cases were positive for CoxA16, 1 068 cases were positive for other enterovirus, 5 cases were positive for mixed infection of EV7l and CoxA16. There was no significant difference in the positive detection rate of enterovirus between sexes. In the past seven years, there was significant difference in the pathogen composition ratio of hand, foot and mouth disease. Conclusion EV7l and CoxA16 are the main pathogens of hand, foot and mouth disease in Urumqi from 2010 to 2016. In order to provide laboratory basis for the prevention and treatment of hand-foot-mouth disease, the surveillance of hand, foot and mouth disease pathogen should be strengthened, especially the detection of other enteroviruses in order to provide laboratory basis for the prevention and treatment of hand, foot and mouth disease.
【作者单位】： 乌鲁木齐市疾病预防控制中心;
【分类号】：R181.3;R725.1
，

本文编号：1494195