轻度胃肠炎伴良性婴幼儿惊厥患儿的肠道微生物检测及部分肠黏膜屏障指标观察

发布时间：2018-02-15 04:05

本文关键词： 肠道微生物肠道益生菌群轮状病毒肠黏膜屏障微生态轻度胃肠炎伴良性婴幼儿惊厥肠炎　出处：《山东医药》2017年43期 　论文类型：期刊论文

【摘要】：目的探讨患儿肠道内微生物的变化与轻度胃肠炎伴良性婴幼儿惊厥(BICE)之间的关系。方法选择同期收治的BICE患儿50例(A组)、急性轻度胃肠炎患儿50例(B组)以及同期进行体检的健康儿童50例(C组),对三组的肠道内微生物进行检测,并对其部分肠黏膜屏障指标进行观察。结果 A组有24例粪便中检出轮状病毒(阳性率为48.00%),B组有10例粪便中检出轮状病毒(阳性率为20.00%),C组有1例粪便中检出轮状病毒(阳性率为2.00%);组间两两相比,P均0.05。A组粪便中大肠杆菌、肠球菌、乳酸杆菌、双歧杆菌的数量分别为(7.65±2.24)×105、(6.13±2.32)×105、(4.83±1.62)×105、(5.02±1.46)×105CFU/g,B组分别为(8.79±2.31)×105、(7.45±2.28)×105、(6.12±2.47)×105、(5.81±1.86)×105CFU/g,C组分别为(9.87±1.68)×105、(9.12±2.20)×105、(8.35±2.12×105)、(6.82±1.20)×105CFU/g;组间两两相比,P均0.05。A组血清二胺氧化酶(DAO)、一氧化氮(NO)、D-乳酸水平分别为(9.84±4.17)U/L、(0.92±0.39)mmol/L、(156.78±48.25)μmol/L,B组分别为(7.49±2.73)U/L、(0.73±0.25)mmol/L、(102.45±40.45)μmol/L,C组分别为(6.35±1.61)U/L、(0.62±0.21)mmol/L、(86.36±30.12)μmol/L,血清DAO、NO、D-乳酸水平组间两两相比,P均0.05。结论 BICE患儿肠道内轮状病毒阳性率增高、各类益生菌群数量降低及肠黏膜屏障能力降低,以上原因可能与BICE的发病有关,但致病机制尚不明确。
[Abstract]:Objective to investigate the relationship between the changes of intestinal microorganism in children with mild gastroenteritis and benign infantile convulsion (BICE). Methods 50 patients with BICE and 50 patients with acute mild gastroenteritis were treated in the same period. A total of 50 healthy children in group C were examined for intestinal microbes in three groups. Results rotavirus was detected in 24 cases of feces in group A (positive rate was 48.00%) and rotavirus was detected in 10 cases in group B (positive rate was 20.00%) in 1 case of feces in group C (positive rate was 20.00%). The positive rate of the virus was 2.00%, and the fecal Escherichia coli in the two groups was 0.05.A, the positive rate was 2.00%, and the positive rate was 2.00%. Enterococcus, Lactobacillus, The amount of Bifidobacterium in group B was 8.79 卤2.31 脳 105 卤2.28) 脳 1057.45 卤2.28) 脳 1057.45 卤2.28) 脳 1055.12 卤2.47) 脳 105CFU 6.81 卤1.86) 脳 105CFU 卤1.62 卤9.87 卤1.68) 脳 10555.12 卤2.20) 脳 105p / r 9.35 卤2.20 脳 1055.35 卤2.52 卤1.82 卤1.20 渭 mol / L, respectively. Conclusion the positive rate of rotavirus in intestinal tract in children with BICE is higher than that in control group. The number of probiotics and the ability of intestinal mucosal barrier were decreased, which may be related to the pathogenesis of BICE, but the pathogenetic mechanism is not clear.
【作者单位】：南京医科大学附属儿童医院;
【分类号】：R725.7;R742.1

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