福建省4岁以下儿童手足口病再次罹患特征的队列分析

发布时间：2018-02-16 07:55

本文关键词： 手足口病再次罹患队列研究流行病学　出处：《福建医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的探讨福建省4岁儿童手足口病再次罹患特征,为制定防控策略提供依据。方法运用队列研究方法以福建省手足口病监测资料中4岁患儿为研究对象,以首次罹患时的特征作为其再次罹患的影响因素,采用SAS 9.0软件的logistic逐步回归法筛选。结果共纳入研究对象82 949例,其中多次罹患者2 612例(3.15%)。在多次罹患者中,累计罹患2次者2 510例,3次者98例,4次者3例,5次者1例。年龄2岁和2岁者首次罹患时,其再次罹患风险分别是年龄为3岁者的4.39(95%CI:3.80~5.07)倍和2.73(95%CI:2.35~3.18)倍;以居住地区6岁儿童手足口病患病率2%为对照,患病率4%、3%~4%和2%~3%的再次罹患风险分别为2.15(95%CI:1.88~2.45)倍、2.10(95%CI:1.85~2.38)倍和1.65(95%CI:1.44~1.89)倍;在妇幼保健机构就诊者再次罹患风险是在非妇幼保健机构就诊者的1.64(95%CI:1.51~1.78)倍;男性再次罹患风险是女性的1.34(95%CI:1.23~1.46)倍。引起再次罹患的主要病原是肠道病毒(EV)71型(33/60),再次罹患可进展为重症病例(8/2612);首次、再次罹患的致病病原有可能均为EV71型毒株(3/6)。结论是否重复罹患与其再次接触病原体的机会密切相关,对首次罹患的低龄幼儿应及时采取干预措施。
[Abstract]:Objective to investigate the reattack characteristics of HFMD in 4-year-old children in Fujian Province, and to provide evidence for the formulation of prevention and control strategies. Methods A cohort study was carried out on 4-year-old children with HFMD surveillance data in Fujian Province. The characteristics of the first attack were used as the influencing factors, and the logistic stepwise regression method of SAS 9.0 software was used to screen the patients. Results A total of 82 949 subjects were included in the study, 2 612 of whom suffered from multiple attacks (3.15%). There were 2 510 cases with 2 510 cases and 3 cases with 3 times and 3 cases with 4 times and 1 case with 5 times. At the first attack of 2 years old and 2 years old, the risk of the second attack was 4.3995 CI: 3.805.07 and 2.73 95% CI2.353.18, respectively. The prevalence rate of HFMD in children aged 6 years in the residential area was 2%. The risk of reattack was 2.15% and 2%, respectively, 2.1095% and 1.65% respectively. The risk of reattack in MCH was 1.6495 CI 1.51% and 1.65 95% 1.51% respectively, and the risk was 1.6495 CI 1.51% 1.78 times higher than that in non-MCH institutions. The risk of reinfection in men is 1.3495 CI: 1.231.46). The main cause of resuscitation is the enterovirus EVS71 (33 / 60%), which can progress to 8 / 2612% of severe cases again; for the first time, Conclusion it is closely related to the chance of repeated exposure to the pathogen, and the intervention should be taken in time for the young children who first suffer from the disease.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R725.1

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