癫痫患儿末梢血中锌、铜水平变化及意义

发布时间：2018-02-26 04:06

  本文关键词： 癫痫 锌 铜 儿童　出处：《山东医药》2017年29期 　论文类型：期刊论文

【摘要】：目的探讨癫痫患儿末梢血中微量元素锌、铜水平变化及其意义。方法 58例癫痫患儿为病例组,按照病程将其分为A组(1年)(n=21)、B组(1~3年)(n=14)、C组(3~5年)(n=13)、D组(≥5年)(n=10),根据脑电图异常程度将其分为轻度异常组(n=23)、中度异常组(n=17)、重度异常组(n=18),根据癫痫患儿上次癫痫发作距本次采血的时间将其分为A1组(10 d)(n=19)、B1组(11~30 d)(n=22)、C1组(31~90 d)(n=10)、D1组(≥91 d)(n=7);并于同期随机选取30例健康体检儿童作为对照组。采用BH5100型钨舟原子吸收光谱仪测定末梢血中锌、铜水平。结果病例组末梢血中锌水平低于对照组,铜水平高于对照组(P均0.05)。B、C、D组锌水平低于A组,C、D组低于B组,D组低于C组(P均0.05);各组末梢血中铜水平比较,P均0.05。重度异常组、中度异常组锌水平低于中度异常组,且重度异常组低于中度异常组(P均0.05);各组末梢血中铜水平比较,P均0.05。B1、C1、D1组末梢血锌水平高于A1组,C1、D1组高于B1组,D1组高于C1组(P均0.05);各组末梢血中铜水平比较,P均0.05。结论癫痫患儿末梢血中锌水平降低、铜水平升高,血液中锌水平与脑电图异常程度、病程、癫痫发作距采血时间有关。
[Abstract]:Objective to investigate the changes and significance of trace elements zinc and copper in peripheral blood of children with epilepsy. According to the course of the disease, the patients were divided into group A (1 year, 1 ~ 3 years) and group C (3 ~ 5 years). According to the degree of abnormal EEG, they were divided into mild abnormal group, moderate abnormal group, severe abnormal group and severe abnormal group. According to the degree of EEG abnormality, they were divided into two groups: mild abnormal group, moderate abnormal group, severe abnormal group, and according to the last epileptic seizure in children with epilepsy. The blood samples were divided into A 1 group (n = 10 d) and C _ 1 group (n = 30 d). The serum zinc in peripheral blood was determined by BH5100 Tungsten Boat Atomic absorption Spectrometer (BH5100), and 30 healthy children were randomly selected as the control group (鈮，

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