儿童初发原发性肾病综合征伴高凝状态57例临床分析

发布时间：2018-02-26 14:34

本文关键词： 原发性肾病综合征高凝状态儿童　出处：《临床儿科杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨儿童初发原发性肾病综合征(PNS)伴高凝状态的临床特征、影响因素。方法回顾分析57例初发PNS患儿的临床资料,并对高凝状态组、非高凝状态组,以及20例正常对照组的临床特征及治疗情况进行比较,同时分析高凝状态下单纯型肾病组(SNS)和肾炎型肾病组(NNS)的差异,并进行相关性分析。结果 57例患儿中,高凝状态组50例,非高凝状态组7例,两组间性别、年龄及临床表现差异均无统计学意义(P0.05);高凝状态组的血小板数目(PLT)、血小板压积(PCT)、白蛋白(Alb)、纤维蛋白原(Fib)、D-二聚体(D2)与正常对照组比较差异有统计学意义(P0.01);高凝状态组和非高凝状态组在PLT、Fib、D2、补体C4水平差异有统计学意义(P0.05)。50例高凝状态患儿中,SNS组(32例)和NNS组(18例)的HCT、TC、LDL、PT、补体C3水平差异有统计学意义(P0.05);HCT与补体C3呈显著正相关(r=0.30,P0.05),PLT与其他指标无显著相关性(P0.05)。57例患儿经治疗后无血栓事件发生,病情好转。结论初发PNS患儿多伴有不同程度的高凝状态,PLT、Fib、D2可作为高凝状态严重程度的参考指标,补体系统激活与高凝状态发生发展可能相关。
[Abstract]:Objective to investigate the clinical features and influencing factors of primary nephrotic syndrome (PNS) with hypercoagulability in children. Methods the clinical data of 57 children with primary PNS were retrospectively analyzed, and the clinical data of hypercoagulability group and non-hypercoagulable state group were analyzed retrospectively. The clinical characteristics and treatment of 20 cases of normal control group were compared, and the difference of SNS (simple nephropathy group) and NNSs (nephritis nephropathy group) in hypercoagulable state was analyzed, and the correlation analysis was carried out. There were 50 cases in hypercoagulability group and 7 cases in non-hypercoagulable group. There was no significant difference in age and clinical manifestations (P 0.05); the number of platelet in hypercoagulable group was significantly different from that in normal control group (P 0.01), and that in hypercoagulable state group was significantly higher than that in hypercoagulable state (P < 0.01). The difference of complement C4 levels between NNS group and non-hypercoagulant group was statistically significant (P 0.05). There was a significant positive correlation between NNS group (n = 18) and NNS group (n = 18). There was a significant positive correlation between complement C _ 3 and complement C _ 3. There was a significant positive correlation between complement C _ 3 and complement C _ 3. There was no significant correlation with other indexes. There was no thrombotic event in 57 children after treatment. Conclusion PLT Fib D 2 can be used as a reference index for the severity of hypercoagulability in children with primary PNS. The activation of complement system may be related to the occurrence and development of hypercoagulability.
【作者单位】：重庆医科大学附属儿童医院肾内科儿童发育疾病研究教育部重点实验室;成都市第三人民医院儿科;
【基金】：国家自然科学基金(No.81270802,81470946,81200520)
【分类号】：R726.9

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