加减资生丸膏剂治疗儿童哮喘肺脾气虚证的疗效观察

发布时间：2018-02-26 21:36

  本文关键词： 资生丸 膏方 儿童哮喘 肺脾气虚 临床研究　出处：《黑龙江中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：观察加减资生丸膏剂治疗儿童支气管哮喘(肺脾气虚证)的临床疗效。方法：将实际符合儿童哮喘肺脾气虚证的69例患儿,按随机数字表法分为加减资生丸膏剂治疗组和孟鲁司特钠片对照组,其中膏剂治疗组为35例,西药常规对照组34例,两组均为5-14岁哮喘患儿。疗程3个月,随访3个月。治疗1个月后对比两组治疗前后临床总体疗效、中医症状积分、肺功能中的小气道功能恢复情况、大气道PEF和FEV1对比治疗前后改善情况、哮喘患儿发作次数及生活质量状况。疗程结束后,随访3个月,观测两组患儿复发情况以及安全性监测情况。此观察研究应用SPSS19.0或SAS 8.1统计学软件进行数据分析。结果：1.临床总体疗效情况。治疗组治疗后临床痊愈9例(25.71%),显效17例(48.57%),有效8例(22.86%),无效1例(2.86%)；对照组治疗后临床痊愈5例(14.71%)显效9例(26.47%)有效15例(44.12%)无效5例(14.71%),且愈显率治疗组74.30%,对照组41.20%,膏剂治疗组明显优于西药常规对照组(P0.01)；而两组总有效率经比较,差异无统计学意义(P0.05)；2.中医单项证候积分情况。治疗组大便溏薄、面白少华、神疲、倦怠、形体消瘦、纳差、气短等证候积分情况,治疗组优于对照组(P0.05),并两组治疗后明显优于治疗前(P0.05),具有统计学意义；3.肺功能情况。小气道功能指标FEF25%、FEF 50%、FEF75%、MMEF75/25%治疗后均有优于治疗前(P0.05),并治疗组优于对照组(P0.05),具有统计学意义,而PEF及FEV1在治疗前后,无显著差异(P0.05)；4.哮喘患儿发作次数情况。治疗组由哮喘患儿发作(3.54+1.27)次下降至(0.51±0.51)次,而对照组由(3.76±1.33)次下降至(1.38±0.60)次,经统计学比较,治疗组优于对照组(P0.01),治疗后优于治疗前(P0.01),差异具有统计学意义；5.哮喘患儿生活质量情况。治疗组哮喘患儿生活质量由(2.00±0.41)提高到(3.45±0.39),而对照组(1.99±0.51)提高到(2.67±0.41),治疗组优于对照组(P0.01),治疗后明显优于治疗前(P0.01),差异具有统计学意义。6.两组哮喘患儿复发情况。疗程结束后,进行随访3个月,分别从治疗组和对照组临床痊愈及显效的患儿中随机抽取数例哮喘患儿,治疗组18例,复发3例,复发率16.67%；对照组11例,复发8例,复发率72.73%。两组复发率比较,治疗组明显优于对照组,差异具有统计学意义(P0.01)。7.两组安全性情况。两组各项指标检测未见明显异常。并治疗组和对照组进行不良反应统计时,无显著性差异(P0.05)。结论：1.加减资生丸膏剂治疗儿童哮喘愈显率74.30%明显优于对照组41.20%：2.加减资生丸膏剂对儿童哮喘肺脾气虚证中医单项证候改善情况明显优于对照组；3.加减资生丸膏剂改善小气道功能明显优于对照组,但改善大气道功能,如PEF、FEV1,无显著差异；4.加减资生丸膏剂减少哮喘患儿发作次数明显优于对照组；5.加减资生丸膏剂改善哮喘患儿生活质量明显优于对照组；6.加减资生丸膏剂控制哮喘患儿复发情况明显优于对照组；7.加减资生丸膏剂依从性较好,治疗组与对照组比较不良反应,无显著性差异。
[Abstract]:Objective: To observe the treatment of children with bronchial asthma reduction pills paste (lung and spleen deficiency syndrome) clinical curative effect. Methods: 69 cases of the children with asthma pulmonary syndrome, were randomly divided into treatment group and reduction pills paste and Montelukast Sodium Tablets group, the ointment for treatment of 35 cases in the group of Western medicine the conventional control group of 34 cases, two groups of 5-14 year old children with asthma. After 3 months of treatment, follow-up of 3 months. After 1 months of treatment between the two groups before and after treatment of clinical total curative effect, TCM symptom score, lung function in small airway function recovery, PEF and FEV1 before and after the airway compared treatment to improve the situation. The number of asthma attacks in children and the quality of life. After the end of treatment, after 3 months of follow-up, observation of two groups of children with recurrent and security monitoring. The observation and Study on the application of SPSS19.0 or SAS 8.1 statistical software for data analysis. 鏋滐細1.涓村簥鎬讳綋鐤楁晥鎯呭喌.娌荤枟缁勬不鐤楀悗涓村簥鐥婃剤9渚，

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