熄风止动冲剂治疗儿童抽动秽语综合征的临床观察

发布时间：2018-02-28 14:41

本文关键词： 熄风止动冲剂抽动秽语综合征临床观察平肝熄风　出处：《黑龙江中医药大学》2013年硕士论文　论文类型：学位论文

【摘要】：目的：观察熄风止动冲剂治疗儿童抽动秽语综合征的临床疗效方法：将60例入选患儿按就诊顺序随机分为两组,实验组和治疗组各30例,实验组给予熄风止动冲剂口服,对照组给予盐酸硫必利片口服采用耶鲁抽动症整体严重程度量表(YGTSS)评分法及中医证候为指标,临床对比观察了熄风止动冲剂和盐酸硫必利片对抽动秽语综合征患者抽动症状及中医证候的改善情况,观察其不良反应。结果：1.两组治疗前分别和治疗4周、8周后进行组内比较,耶鲁抽动积分前后差异均有高度统计学意义(P＜0.01),两组治疗4周后和治疗8周后分别进行组内比较,耶鲁抽动积分前后差异均有高度统计学意义(P0.01)。两组治疗前、治疗4周后和8周后分别进行组间比较,耶鲁抽动积分差异无统计学意义(P0.05)。 2.实验组与对照组治疗前与治疗4、8周后分别进行组内比较,治疗组中医证候积分差异均有高度统计学意义(P0.01),而对照组差异无统计学(P0.05)。治疗后4周和治疗后8周进行组间比较,实验组中医证候积分差异有高度统计学意义(P0.01)。 3.对照组在嗜睡、头晕、乏力、心率加快方面,不同程度的出现,实验组2例出现消化道反应,实验组和对照组在头晕、乏力方面比较有统计学意义(P0.05)。结论：1.实验组和对照组能明显改善抽动抽动秽语综合征患儿的抽动症状,并且疗效相当,治疗8周的疗效较4周更为显著。 2.熄风止动冲剂能显著的改善患儿的中医证候,而盐酸硫必利则无显著效果。 3.熄风止动冲剂安全、无副作用,而盐酸硫必利则可出现不同程度的副作用。
[Abstract]:Objective: to observe the clinical effect of Xifeng Zhihe granule on children with Tourette syndrome. Methods: 60 children were randomly divided into two groups: experimental group (n = 30) and treatment group (n = 30). The control group was given tiapride hydrochloride orally with YGTSS score and TCM syndrome as the index. The improvement of symptoms and syndromes of Tourette syndrome in patients with Tourette's syndrome by Xifeng Zhifei granules and tiapride hydrochloride tablets were compared and the adverse reactions were observed. Results before and after 4 weeks and 8 weeks of treatment, there were significant differences in Yale tic score between the two groups (P < 0.01). The differences between the two groups were compared after 4 weeks of treatment and 8 weeks after treatment. The difference of Yale tic score before and after treatment was statistically significant (P 0.01). Before treatment, 4 weeks after treatment and 8 weeks after treatment, there was no significant difference in Yale tic score between the two groups (P 0.05). 2.Compared with the control group before treatment and 4 weeks after treatment, the difference of TCM syndromes in the treatment group was highly statistically significant (P 0.01), but there was no significant difference in the control group (P 0.05). The difference between the two groups was compared 4 weeks after treatment and 8 weeks after treatment. The difference of TCM syndromes in the experimental group was statistically significant (P 0.01). 3. In the control group, there were different degrees of drowsiness, dizziness, fatigue and heart rate acceleration. In the experimental group, there were 2 cases of digestive tract reaction, while in the experimental group and the control group, there were significant differences in dizziness and fatigue (P 0.05). Conclusion1.The experimental group and the control group can obviously improve the symptoms of Tourette syndrome, and the curative effect is similar, and the curative effect is more obvious in the 8th week than in the 4th week. 2. Xifengzhi granule can significantly improve TCM syndromes of children, but thiapride hydrochloride has no significant effect. 3. Xifeng Zhi granule is safe and has no side effects, while thiopride hydrochloride can have different side effects.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R272

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