采用德尔菲法构建基于全面触发工具法的儿童药品不良事件触发器

发布时间：2018-03-04 19:55

本文选题：德尔菲法　切入点：触发器　出处：《中国药学杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的采用德尔菲(Delphi)法构建儿童住院患者药品不良事件(ADE)的触发器,为临床开展基于全面触发工具(GTT)的ADE主动监测提供参考。方法参考GTT白皮书和相关文献中的触发器,通过专家预调查,形成触发器初始条目,并在此基础上设计专家咨询问卷。选取北京、上海等省市的27名专家,采用Delphi法进行两轮专家咨询,对触发器条目进行筛选、修改。结果问卷回收率为92.6%、100%,两轮咨询后专家权威程度系数(Cr)为0.81±0.05,专家意见的变异系数(CV)为0.29±0.13,专家意见的协调系数(W)为0.346,经检验具有统计学意义(P0.001)。最终确定触发器36个,包括实验室指标20个,解毒剂9个,临床症状4个,干预措施3个。结论采用Delphi法构建的儿童ADE触发器合理可行,为GTT法的实施奠定了基础。
[Abstract]:Using Delphy (Delphi) was constructed with adverse drug events in hospitalized children (ADE) trigger for clinical comprehensive trigger tool based on (GTT) ADE active monitoring to provide reference. The reference to GTT white paper and related literature in pre flop, through expert investigation, the formation of the initial trigger entry, and then design expert consultation questionnaire based on the selection of 27 experts. Beijing, Shanghai and other provinces and cities, carried out two rounds of expert consultation by using Delphi method, the trigger items were screened. The results of the questionnaire to modify the rate of recovery was 92.6%, 100%, the two round of consultation after the expert authority coefficient (Cr) was 0.81 + 0.05, the coefficient of variation (CV) for expert advice 0.29 + 0.13, the coordination coefficient of expert opinion (W) is 0.346, which is proved to have statistical significance (P0.001). The final trigger 36, including laboratory index 20, 9 clinical symptoms of 4 antidotes, and intervention measures 3 Conclusion the ADE trigger of children constructed by Delphi is reasonable and feasible, which lays the foundation for the implementation of the GTT method.

【作者单位】：重庆医科大学附属儿童医院药学部儿童发育疾病研究教育部重点实验室;重庆医科大学附属儿童医院血液科;
【基金】：2015中国医师协会科研建设项目(编号44) 重庆市科委民生项目(cstc2016shmszx130048) 重庆市卫计委医学科研项目(2016ZDXM017)
【分类号】：R985

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