肾病综合征患儿血清同型半胱氨酸水平变化及临床意义

发布时间：2018-03-09 05:04

本文选题：同型半胱氨酸　切入点：儿童　出处：《山西医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:比较肾病综合征患儿血清同型半胱氨酸水平变化并观察其血同型半胱氨酸浓度与血浆白蛋白的相关性,分析其原因及临床意义。方法:收集2016年1月至2017年2月就诊于山西医科大学和山西省儿童医院首次确诊为肾病综合征的患儿30例,同时选取非肾病综合征儿童30例,于清晨空腹抽取4ml血液,然后采用ELISA检测两组儿童血清同型半胱氨酸水平,并检测患儿血清白蛋白浓度;采用SPSS 18.0分析两组儿童血清Hcy的变化以及患儿Hcy与白蛋白之间的关系;最后结合临床,分析数据意义。结果:1.肾病综合征患儿中有血清Hcy浓度的均数为11.310±3.568μmol/L,对照组中为7.373±2.444μmol/L,两组数据经协方差分析后得P0.001,差别具有统计学意义;2.肾病综合征患儿血浆Hcy浓度与白蛋白呈正相关。结论:1.HHcy不仅可以导致肾小球硬化,而且还可以促进血栓形成,而本研究发现肾病综合征患儿体内存在不同程度的HHcy,因此减少Hcy浓度可能延缓肾脏损害,降低NS患儿肾静脉血栓形成的几率。2.Hcy在血浆中大部分是以与白蛋白结合的结合型存在,血清Hcy与白蛋白浓度呈正相关,所以由于尿蛋白排出导致的低蛋白血症可能影响血浆Hcy浓度。
[Abstract]:Objective: to compare the changes of serum homocysteine level in children with nephrotic syndrome and to observe the correlation between serum homocysteine concentration and plasma albumin. Methods: from January 2016 to February 2017, 30 children with nephrotic syndrome were selected from Shanxi Medical University and Shanxi Children's Hospital, and 30 children with non-nephrotic syndrome were selected. The serum homocysteine level and serum albumin concentration were measured by ELISA, the changes of serum Hcy and the relationship between Hcy and albumin in the two groups were analyzed by SPSS 18.0. Finally, combined with clinical practice, The mean of serum Hcy concentration in children with nephrotic syndrome was 11.310 卤3.568 渭 mol / L, and that in control group was 7.373 卤2.444 渭 mol / L. The results of covariance analysis showed that the difference was statistically significant (P 0.001). The plasma Hcy concentration in children with nephrotic syndrome was significantly higher than that in control group (P < 0.05). Conclusion: 1. HHcy can not only cause glomerulosclerosis, This study also found that children with nephrotic syndrome had different levels of Hcy, so reducing the concentration of Hcy might delay renal damage. Reducing the probability of renal venous thrombosis in NS children. 2. Most of Hcy in plasma is bound to albumin, and serum Hcy is positively correlated with albumin concentration. So hypoproteinemia due to urinary protein excretion may affect plasma Hcy concentration.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R726.9

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