亚低温对重症病毒性脑炎患儿血清及脑脊液NSE、S100B蛋白表达的影响

发布时间：2018-03-09 14:02

本文选题：病毒性脑炎　切入点：亚低温　出处：《华中科技大学学报(医学版)》2017年03期 　论文类型：期刊论文

【摘要】：目的研究亚低温治疗对小儿重症病毒性脑炎患者血清及脑脊液神经元特异性烯醇化酶(NSE)、S100B蛋白水平的影响。方法以2012年1月~2014年12月武汉儿童医院收治的83例重症病毒性脑炎患儿为研究对象,随机分为亚低温组和常规治疗组,亚低温组于入院24h内实施全身亚低温治疗(目标温度为肛温32~35℃,疗程3~10d),对照组给予常规治疗。观察患儿治疗前后临床症状,监测血清及脑脊液NSE、S100B蛋白水平。结果 (1)与常规治疗组比较,亚低温治疗组患儿临床症状持续时间、格拉斯哥昏迷指数(GCS)评分以及住院时间明显缩短(P0.05或P0.01);(2)两组血清NSE、S100B含量在治疗后0、24h比较差异无统计学意义(均P0.05),在治疗后48、72h及10d,亚低温治疗组患儿血清NSE、S100B水平低于常规治疗组,两组差异有统计学意义(P0.05或P0.01);(3)恢复期亚低温治疗组脑脊液NSE、S100B水平均低于常规治疗组,差异具有统计学意义(P0.05或P0.01)。结论亚低温治疗可以降低重症病毒性脑炎患儿血清及脑脊液NSE、S100B蛋白水平,改善临床症状。
[Abstract]:Objective to study the effect of mild hypothermia therapy on serum and cerebrospinal fluid neuron-specific enolase S100B protein levels in children with severe viral encephalitis. Methods from January 2012 to December 2014, 83 patients with severe viral encephalitis were treated in Wuhan Children's Hospital. Children with viral encephalitis were studied. The mild hypothermia group was randomly divided into mild hypothermia group and routine treatment group. The mild hypothermia group was treated with systemic mild hypothermia within 24 hours after admission. The serum and cerebrospinal fluid (CSF) NSES100B protein levels were monitored. Results compared with the routine treatment group, the clinical symptom duration of the mild hypothermia treatment group was longer than that of the routine treatment group. Glasgow coma index (Glasgow coma index) score and hospitalization time were significantly shortened (P 0.05 or P 0.01). There was no significant difference in serum NSES100B levels between the two groups (all P 0.05, P 0.05). The serum NSES100B levels in the mild hypothermia group were lower than those in the routine treatment group at 48 hours and 10 days after treatment. There was significant difference between the two groups (P0.05 or P0.01) the levels of cerebrospinal fluid (CSF) S100B in the mild hypothermia group were lower than those in the routine treatment group. Conclusion mild hypothermia therapy can reduce serum and CSF NSE S100B protein levels and improve clinical symptoms in children with severe viral encephalitis.
【作者单位】：华中科技大学同济医学院附属武汉儿童医院(武汉市妇幼保健院)重症医学科;华中科技大学同济医学院附属协和医院感染科;
【基金】：武汉市卫生计生委医疗卫生科研项目(No.WX14B23)
【分类号】：R725.1

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