病毒性脑炎患儿血清和脑脊液中MMPs与TIMP和PCT及TNF-α指标检测价值研究

发布时间：2018-03-10 10:47

本文选题：病毒性脑炎　切入点：脑脊液　出处：《中华医院感染学杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的探讨病毒性脑炎(VE)患儿血清及脑脊液基质金属蛋白酶(MMPs)、基质金属蛋白酶组织抑制剂(TIMP)、降钙素原(PCT)及肿瘤坏死因子-ɑ(TNF-α)指标水平变化,以期为VE早期诊断提供数据依据。方法选取2013年1月-2016年1月医院就诊VE患儿124例为观察组,另选取本研究组康复后小儿50例为对照组,观察两组血清及脑脊液MMP-2、MMP-9、TIMP-1、PCT、TNF-α水平变化,同时将观察组按照病情严重程度、病情缓急程度划分,观察不同病情严重程度及缓急程度血清及脑脊液观察指标变化。结果观察组不同标本间观察指标对比,差异均有统计学意义(P0.05),观察组同标本同项指标均高于对照组(P0.05),观察组病情为轻度71例、重度53例,重度患儿同标本同项指标均高于轻度患儿(P0.05),观察组急性82例,非急性42例,急性患儿同标本同项指标均高于非急性患儿(P0.05)。结论 MMPs、TIMP、PCT及TNF-α均参与VE发生及发展过程,监测其血清及脑脊液PCT、TNF-α水平对中枢神经系统感染具有定性作用,综合监测具有评估疾病发展情况,预测治疗结局作用。
[Abstract]:Objective to investigate the changes of serum and cerebrospinal fluid matrix metalloproteinase (MMPsN), tissue inhibitor of matrix metalloproteinase (TIMP), procalcitonin (PCT) and tumor necrosis factor- (TNF- 伪) in children with viral encephalitis (VEV). Methods from January 2013 to January 2016, 124 children with VE were selected as observation group and 50 children in this study group as control group. The changes of serum and CSF levels of MMP-2MMP-9TIMP-1and PCTNF- 伪 were observed in both groups. At the same time, the observation group was divided into two groups according to the severity of the disease and the degree of priority of the disease, and the changes of serum and cerebrospinal fluid (CSF) were observed according to the severity of the disease and the degree of urgency. Results the observed indexes were compared among the different specimens of the observation group. The difference was statistically significant (P 0.05). The same items in the observation group were higher than those in the control group (P 0.05). In the observation group, 71 cases were mild, 53 cases were severe, and the same index of the same specimen in the severe group was higher than that in the mild group (P 0.05). In the observation group, there were 82 cases of acute and 42 cases of non-acute. Conclusion the levels of MMPsTIMPnPCT and TNF- 伪 are involved in the pathogenesis and development of VE, and the levels of serum and cerebrospinal fluid PCTNF-a may play a qualitative role in central nervous system infection. Comprehensive monitoring can evaluate the development of disease and predict the outcome of treatment.
【作者单位】：郑州人民医院儿科;贵州医科大学附属医院儿科;郑州市儿童医院东区医院神经内科;郑州人民医院检验科;
【基金】：河南省教育厅科学技术研究重点基金资助项目(142106310017)
【分类号】：R725.1

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