婴儿胆道畸形与巨细胞病毒感染的临床病理分析

发布时间：2018-03-12 06:48

本文选题：巨细胞病毒　切入点：胆道畸形　出处：《重庆医科大学》2012年硕士论文　论文类型：学位论文

【摘要】：目的：探讨婴儿胆道畸形（胆道闭锁、胆道狭窄）与巨细胞病毒感染的关系，了解胆道畸形合并巨细胞病毒感染在临床表现、肝功能、病检结果上的特点。方法：回顾性分析我院收治，经手术造影证实的48例胆道畸形患儿临床资料，根据巨细胞病毒感染与否将病人分组，比较两组患儿在肝功能，肝脏活检病检结果上的异同。结果： 1.48例胆道畸形患儿中，合并巨细胞病毒感染22例，占45.8%。37例胆道闭锁患儿中，感染组17例与非感染组20例的γ-GT、ALP及小胆管增生程度有显著性差异(P0.05)；11例胆道狭窄患儿中，感染组5例与非感染组6例在肝功能及病检结果上无显著性差异。 2.37例胆道闭锁患儿与11例胆道狭窄患儿相比，在巨细胞病毒感染率上无显著性差异，在γ-GT及小胆管增生程度上存在显著性差异(P0.05)；48例胆道畸形患儿中，，小胆管轻度增生组与重度增生组γ-GT、TBA水平存在显著性差异(P0.05)。结论： 1.巨细胞病毒感染可引起胆管上皮细胞受损，引起或加重胆道闭锁患儿的胆管损伤，加重汇管区小胆管增生程度。 2.小胆管增生程度与胆汁淤积程度和胆管上皮细胞受损的严重程度存在相关性。
[Abstract]:Objective:. To investigate the relationship between biliary malformation (biliary atresia, biliary stricture) and cytomegalovirus infection in infants. Methods:. The clinical data of 48 children with biliary tract malformation confirmed by surgical angiography were analyzed retrospectively. According to cytomegalovirus infection or not, the differences and similarities of liver function and liver biopsy were compared between the two groups. Results:. 1.Among 48 children with biliary malformation, 22 cases were complicated with cytomegalovirus infection, accounting for 45.8.37 cases of biliary atresia. There were significant differences in 纬 -GThelP and hyperplasia of small bile duct in 17 cases of infection group and 20 cases of non-infection group in 11 cases of biliary stricture. There was no significant difference in liver function and pathological examination results between the infection group (5 cases) and the non-infected group (6 cases). 2.There was no significant difference in cytomegalovirus infection rate between 37 children with biliary atresia and 11 children with biliary stricture, but there was significant difference in 纬 -GT and the degree of hyperplasia of small bile duct in 48 patients with biliary tract malformation. There was significant difference in TBA level between mild hyperplasia group and severe hyperplasia group (P 0.05). Conclusion:. 1. Cytomegalovirus infection can damage bile duct epithelial cells, cause or aggravate bile duct injury in children with biliary atresia, and aggravate the degree of hyperplasia of small bile duct in catchment area. 2. The degree of small bile duct hyperplasia was correlated with the degree of cholestasis and the severity of bile duct epithelial cell damage.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R726.5

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