不同剂量维生素E在早产儿贫血预防中的临床疗效观察

发布时间：2018-03-16 16:33

本文选题：维生素E　切入点：早产儿贫血　出处：《山东大学》2012年硕士论文　论文类型：学位论文

【摘要】：目的：探讨不同剂量VitE在预防早产儿贫血中的临床疗效。方法：选择我院NICU病房2009年10月至2011年10月收治的早产儿60例,按入院先后顺序随机分组为A、B、C3组。A组为对照组：20例,常规早产儿奶粉喂养及部分静脉营养支持治疗。在上述对照治疗的基础上,入院后第3天起给予口服不同剂量的VitE为治疗组,连用4周。B组为小剂量组：20例,VitE5mg/kg.qd；C组为大剂量组：20例,VitE30mg/kg.qd。观察治疗过程中各组红细胞(RBC)、血红蛋白(Hb)、红细胞压积(Hct)、网织红细胞(Ret)及其治疗前后血清Vi tE浓度的变化情况。结果：B、C组患者治疗后红细胞(RBC)、血红蛋白(Hb)、红细胞压积(Hct)、网织红细胞(Ret)均有改善,各项指标改善程度均优于A组(P0.05),R与C组各项指标改善程度对比差别无统计学意义(P0.05)。B、C组患者治疗后血清VitE的浓度均明显升高,且差别有统计学意义(P0.05),A组患者血清中VitE浓度明显下降。结论：1、早产儿生后3天均应开始补充VitE,推荐剂量Vi tE5mg/kg.d,为最佳用药剂量。2、应用以上VitE剂量,可降低早产儿贫血的发生,减少输血频次。3、以上剂量血清中VitE的浓度是安全的,符合生理需要量,临床未发现不良反应。
[Abstract]:Objective: to investigate the clinical effect of different doses of VitE on prevention of anemia in premature infants. Methods: 60 premature infants were selected from October 2009 to October 2011 in NICU ward of our hospital. 20 cases of control group were randomly divided into group A (group A) and group A (n = 20). Routine premature infants were fed with milk powder and partial intravenous nutrition support. On the basis of the above control treatment, oral VitE with different doses was given to the treatment group from the third day after admission. After 4 weeks of treatment, 20 patients in group B were treated with small dose of Vitamin E 5 mg / kg / kg 路qdN C, and 20 cases in Group C were treated with Vitamin E 30 mg / kg 路qd.The changes of serum VitE concentrations in each group were observed during the course of treatment, such as RBC, HBC, HCT, reticulocyte (Ret) and before and after treatment. Results after treatment, RBC, HB, HCT, Ret of reticulocyte in group C were improved. The improvement degree of each index was better than that of group A (P 0.05) and group C (P 0.05). There was no significant difference in the improvement degree between group A and group C. The serum VitE levels of patients in group P0.05 were significantly higher than those in group C after treatment. There was a significant difference in serum VitE concentration in P0.05A group. ConclusionVit should be replenished 3 days after birth in premature infants. The recommended dose of Vi tE 5 mg / kg 路d was the best dose of Vi tE 5 mg / kg 路d. The above dose of VitE could reduce the incidence of anemia and reduce the frequency of blood transfusion. The concentration of VitE in serum at the above dose was safe. In accordance with physiological requirements, no adverse reactions were found clinically.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R722.6

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