单纯性肥胖儿童脂肪因子和炎症因子相关性研究

发布时间：2018-03-16 23:17

本文选题：肥胖儿童　切入点：脂肪因子　出处：《中国地方病防治杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的探讨肥胖儿童人群中炎症因子高敏感度C-反应蛋白(hs-CRP)与脂肪因子、体质指数(BMI)、腰围(WC)之间关系。方法选取单纯肥胖儿童8-14岁(肥胖组)50例,正常儿童(正常组)30例。测定两组对象身高、体重,计算BMI[BMI=体重(kg)/身高(m~2)],采用软尺测量WC;取空腹静脉血3ml,测定hs-CRP;酶联免疫法测定血清脂联素(ug/ml),放射免疫分析法测定血清瘦素(ng/ml)。结果肥胖组BMI、WC、瘦素及hs-CRP结果值明显高于正常组(P0.05);肥胖组脂联素结果明显低于正常组(P0.05);肥胖儿童组血清hs-CRP与BMI、WC和瘦素呈正相关(P0.05),与脂联素呈负相关(P0.05)。结论脂联素、瘦素、WC、BMI与hs-CRP密切相关,肥胖儿童血清脂联素明显降低,hsCRP明显升高,其可以作为判断相关病情和进展的有效指标。
[Abstract]:Objective to investigate the relationship between high sensitivity C-reactive protein (hs-CRP) and fat factor, body mass index (BMI) and waist circumference (WCC) in obese children. Methods 50 obese children aged 8 to 14 years (obese group) were selected. Normal children (normal group, 30 cases). The height and weight of the two groups were measured. BMI was calculated and measured by soft ruler; fasting venous blood was measured by 3ml and hs-CRP; serum adiponectin was measured by enzyme-linked immunosorbent assay (Elisa); serum leptin was measured by radioimmunoassay (RIA). Results the results of BMIWC, leptin and hs-CRP in obese group were significantly higher than those in obese group. The results of adiponectin in obese group were significantly lower than that in normal group P0.05.The serum hs-CRP in obese children was positively correlated with BMI-WC and leptin, and negatively correlated with adiponectin (P0.05). Conclusion adiponectin, adiponectin, adiponectin, adiponectin, adiponectin, adiponectin, adiponectin, and adiponectin in obese children. The serum adiponectin level in obese children was significantly lower than that in the control group. It could be used as an effective index to judge the disease and progression of obese children.
【作者单位】：武汉市第四医院儿科;
【分类号】：R723.14

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