2010-2015年西安市围产儿出生缺陷的流行特征

发布时间：2018-03-17 00:28

本文选题：围产儿　切入点：出生缺陷　出处：《西安交通大学学报(医学版)》2017年03期 　论文类型：期刊论文

【摘要】：目的了解西安市围产儿出生缺陷的动态流行特征,为今后出生缺陷预防工作的重点提供科学依据。方法对2010-2015年西安市所有产科医院上报的出生缺陷资料进行统计描述。结果出生缺陷平均发生率为89.62/104(87.50/104,91.74/104),缺陷发生率逐年上升(χ~2=157.13,P0.01)。出生缺陷发生率位于前5位的依次为:先天性心脏病(26.53/104)、多指(趾)(13.10/104)、总唇腭裂(11.42/104)、神经管缺陷(6.06/104)、先天性脑积水(5.08/104),共占出生缺陷总数的69.39%。其中,先天性心脏病的发生率呈逐年上升趋势(χ2=837.65,P0.01)。出生缺陷发生率城市高于农村(OR=1.108,95%CI:1.056~1.162),男婴高于女婴(OR=1.151,95%CI:1.097~1.208),母亲年龄20岁(OR=1.764,95%CI:1.532~2.032)和母亲年龄≥35岁(OR=1.283,95%CI:1.179~1.395)也是缺陷儿发生的危险因素。缺陷儿以活产居多(72.54%),通过超声和临床诊断的病例各占52.83%和46.24%,产前诊断率为33.20%。结论西安市2010-2015年围产儿出生缺陷发生率总体有增加的趋势,应不断提高各监测点的产前诊断能力,从而降低本地区的缺陷发生水平,提高出生人口素质。
[Abstract]:Objective to investigate the dynamic epidemic characteristics of perinatal defects in Xi'an. Methods the data of birth defects reported by all obstetrical hospitals in Xi'an from 2010 to 2015 were statistically described. Results the average incidence of birth defects was 89.62 / 104 / 87.50 / 104 / 91.74 / 104 / 104, respectively. The incidence of birth defects in the first five places was 26.53%, 10.4%, 13.10%, 11.42%, 6.06%, 6.06%, 5.08% 104%, respectively, which accounted for 69.39% of the total number of birth defects, and the incidence of congenital hydrocephalus was 5.08% 104%, which accounted for 69.39% of the total number of birth defects, and the total cleft lip and palate were 11.42% 10 4%, the nerve tube defects were 6.06% 10 4, and congenital hydrocephalus 5.08% 104%, among them, the incidence of congenital hydrocephalus was 5.08% 104%. The incidence of congenital heart disease is increasing year by year (蠂 2 / 837.65i / P 0.01.The incidence of birth defects in urban areas is higher than that in rural areas: 1.10895 CI: 1.0561.162%, in males 1.15195CI: 1.09771.208, in mothers 20 years old OR1.76495CIW 1.5322.032) and in the cases of mothers over 35 years old: OR1.28395CICell 1.17995 / 1.395. the risk factors for the occurrence of defects are also found in the cases of infants with congenital heart diseases (OR 1.76495 / 95 CI: 1.5322.32) and their mothers aged more than 35 years (OR1.28395CImember 1.179 / 1.395). The number of cases diagnosed by ultrasound and clinical diagnosis was 52.83% and 46.24.The prenatal diagnosis rate was 33.200.Conclusion the incidence of perinatal defects in Xi'an from 2010 to 2015 is increasing. The ability of prenatal diagnosis should be improved continuously in order to reduce the level of defect occurrence and improve the quality of the birth population.
【作者单位】：西安交通大学公共卫生学院流行病与卫生统计学系;西安市妇幼保健院;
【基金】：陕西省卫计委出生缺陷防治课题(No.sxwsjswzfcght2016-013) 国家自然科学基金(No.81230016)~~
【分类号】：R174

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