维生素A、D和E与急性毛细支气管炎在婴儿和年幼的孩子的关系

发布时间：2018-03-19 08:45

本文选题：急性毛细支气管炎　切入点：危险因素　出处：《大连医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：背景:急性毛细支气管炎是世界各地的婴幼儿最常患的一种呼吸道疾病。许多危险因素影响其发病率,父母及医护工作者对其的关注每年都在增加。维生素A、D和E在维护机体生物学功能方面起到重要的作用。这些维生素有免疫调节作用,因此它们的缺乏可以导致各种疾病,尤其是呼吸道疾病。目前认为维生素A、D、E对急性毛细支气管炎有影响,所以本次研究中,比较了不同的因素及其与维生素A、D和E的关系,并试图为临床医生提供重要的预测价值。本研究的价值在于发现维生素A、D和E对于急性毛细支气管炎的作用和其相关危险因素。因此,为这些孩子提供一个治疗和预防维生素缺乏的方法。目的:在这项研究中,我们对6个月到3岁的急性毛细支气管炎儿童进行了多个风险因素的分析,包括性别、母乳喂养史,早产史、出生季节和维生素A、D、E水平。本研究将会为医生提供减少急性毛细支气管炎发病率的方法,并积极补充缺乏的维生素作为早期预防的手段。材料与方法:实验组115例(毛细支气管炎组,没有其他重大的潜在疾病)和114例未感染细支气管炎或其他呼吸道疾病(对照组,没有重大的潜在疾病),病例来自于2015年1月至2017年1月在大连医科大学第一附属医院儿科住院和门诊就诊的儿童,研究比较了维生素A、D、E水平、急性毛细支气管炎相关风险因素的统计学意义。应用spss 21.0统计软件进行统计分析。对连续变量进行均值和标准差描述,分类变量进行百分比描述。T检验比较两个独立样本的关系。χ2检验比较分类变量的关系。单因素方差分析用来比较季节和血清维生素A、D和E水平的关系。此外,应用多因素分析比较特定季节血清维生素D水平的统计学意义。多因素线性回归分析分别比较实验组、对照组特定年龄、性别血清水平的维生素A、D、E和毛细支气管炎相关危险因素的(妊娠、母乳喂养持续时间和季节)关系。p0.05有统计学意义。结果:1.毛细支气管炎组和非毛细支气管炎组之间的比较血清维生素A平均浓度为0.29±0.15mg/L、维生素D为19.77±5.80 ng/L、维生素E为6.30±1.89 mg/L,病例组和对照组在季节(χ2=5.344;p0.001),母乳喂养(χ2=4.262;p=0.039)和妊娠方面(χ2=7.316;p=0.007),差异有统计学意义。同时,这项研究显示,两组的血清维生素A(t=-6.683;p=0.000)和维生素D(t=3.388;p=0.001)水平差异有统计学意义。然而,两组血清维生素E(t=-1.015;p=0.311)水平差异无统计学意义。2.维生素A、D和E独立危险因素的分析a)急性细支气管炎患儿中,母乳喂养不足6个月患儿的血清维生素A水平显著低于母乳喂养超过6个月的患儿(t=5.344;p=0.000)。母乳喂养时间相同时,对照组血清视黄醇水平高于病例组,但差异无统计学意义(t=1.399;p=0.165)。b)只有在毛细支气管炎患者中,血清维生素D水平与季节有关(χ2=12.736;p=0.001)。疾病组的四季维生素D水平差异有统计学意义。本研究结果显示,急性毛细支气管炎患者的维生素D水平,冬季(45.2%)高于春季(25.2%)高于夏天(17.4%)高于秋天(12.2%)。但在对照组中差异无统计学意义。c)从我们的研究结果显示,两组血清维生素E水平在性别、季节,母乳喂养方面差异无统计学意义。3.维生素A、D和E多风险因素分析a)在病例组,只有母乳喂养少于6个月(β=-0.500;p0.001)的患儿喂养时间和血清维生素A水平呈负相关。同时,在对照组中,年龄、性别、孕期,母乳喂养、季节与血清维生素A浓度无关。b)在病例组中,季节(β=0.419;p0.05)与血清维生素D水平相关。在对照组中,血清维生素D浓度与年龄、性别、孕期、季节和母乳喂养无关。c)在病例组中,孕期(β=0.464;p=0.001)与儿童血清维生素E浓度相关。在对照组中,血清维生素E浓度与年龄、性别、季节、孕期和母乳喂养无关。结论:1.维生素A和D有急性毛细支气管炎的重大关系。2.独立危险因素分析发现急性毛细支气管炎与维生素A和维生素D水平相关。而多危险因素分析发现这三种维生素(A、D、E)与急性细支气管炎相关。3.补充这些维生素可以作为预防3岁以下儿童急性毛细支气管炎发作的重要措施。
[Abstract]:Background: acute bronchiolitis is a respiratory disease around the world. Most infants often suffer from many risk factors affecting the incidence, parents and health care workers to its attention is increasing year by year. Vitamin A, D and E play an important role in maintaining the biological function of these vitamins can regulate. The lack of immunity, so they can lead to various diseases, especially respiratory diseases. The vitamin A, D, E of acute bronchiolitis have influence, so in this study, compare the different factors and vitamin A, D and E, and to provide an important predictive value for clinicians. The value of this research lies in the discovery of vitamin A, D and E for acute bronchiolitis and its related risk factors. Therefore, to provide a method for the prevention and treatment of vitamin deficiency for these children. Objective: in this study, we for 6 months to 3 years of acute bronchiolitis in children were analyzed, several risk factors including gender, breastfeeding history, preterm birth, birth season and vitamin A, D, E level. The study will provide methods to reduce the incidence of acute bronchiolitis as a doctor, and to supplement the lack of vitamins as a means of early prevention. Materials and methods: 115 cases of the experimental group (bronchiolitis group, no other major potential disease) and 114 cases without infection bronchitis or other respiratory diseases (control group, no significant underlying disease), from January 2015 to January 2017 in the case the First Affiliated Hospital of Dalian Medical University pediatric inpatient and outpatient children compared with vitamin A, D, E, acute bronchiolitis risk factors associated with statistical significance. The application of SPSS 21 Statistical software for statistical analysis of continuous variables. The mean and standard deviation of the percentage of description, description of.T test between two independent samples of the relationship between categorical variables. The relationship between these 2 classification variables. Single factor analysis of variance was used to compare the seasonal and serum vitamin A, D and E levels. In addition, multiple factors analysis of statistical significance between the specific seasonal levels of serum vitamin D. Multivariate linear regression analysis were compared between the experimental group and the control group of gender specific age, serum levels of vitamin A, D, E and bronchiolitis related risk factors (pregnancy, breastfeeding duration and seasonal) have statistical significance. Results: compared with.P0.05 the average serum vitamin A concentration between 1. bronchiolitis group and non bronchiolitis group was 0.29 + 0.15mg/L, 19.77 + 5.80 ng/L of vitamin D, vitamin E is 6.30 + 1.89 Mg/L, the case group and the control group in the season (2=5.344; p0.001), breastfeeding (2=4.262; p=0.039) and pregnancy (2=7.316; p=0.007), the difference was statistically significant. At the same time, this study shows that two groups of serum vitamin A (t=-6.683; p=0.000) and vitamin D (t=3.388 p=0.001); statistically significant difference level. However, the two groups of serum vitamin E (t=-1.015; p=0.311) no significant differences were found in.2. of vitamin A, analysis of independent risk factors D and E a) in children with acute bronchiolitis in children with insufficient breastfeeding for 6 months the serum vitamin A level was significantly lower than that of breastfeeding for more than 6 months of children (t=5.344; p=0.000). Breast feeding at the same time, the level of serum retinol group was higher than the case group, but the difference was not statistically significant (t=1.399; p=0.165).B) only in capillary bronchitis patients, serum levels of vitamin D associated with seasonal (x 2=12.736; p=0.001). There were statistically significant differences in four levels of vitamin D in disease group. The results of this study showed that patients with acute bronchiolitis vitamin D levels in winter (45.2%) than in spring (25.2%) is higher than that of summer (17.4%) was higher than in autumn (12.2%). But no significant difference in the control group on the.C display) from the results of our study, the serum vitamin E level in the two groups in gender, seasonal differences, breastfeeding was not statistically significant.3. of vitamin A, D and E analysis of risk factors of a) in the patient group, only breastfed for less than 6 months (P =-0.500; p0.001) was negatively correlated with feeding time and serum vitamin the level of A. At the same time, in the control group, age, sex, pregnancy, breast-feeding, the season has nothing to do with the serum concentration of vitamin A.B) in case group, season (beta =0.419; P0.05 D) associated with the levels of serum vitamin. In the control group, serum vitamin D concentration With the age, sex, pregnancy, breast-feeding season and independent.C) in case group, pregnancy (beta =0.464; p=0.001) associated with children's serum vitamin E concentration. In the control group, serum vitamin E concentration and age, sex, season, pregnancy and breastfeeding. Conclusion: 1. of vitamin A and D there are significant independent risk factors of acute.2. bronchiolitis of acute bronchiolitis with vitamin A and vitamin D levels. And the multiple risk factor analysis found that the three kinds of vitamins (A, D, E) associated with acute bronchiolitis.3. these vitamin supplements can be used as an important measure to prevent children under 3 years old with acute bronchitis attack.

【学位授予单位】：大连医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R725.6

【相似文献】