陕西省育龄妇女围孕期服用叶酸与产儿先天性心脏病的关系

发布时间：2018-03-20 10:27

  本文选题：先天性心脏病　切入点：叶酸服用　出处：《西安交通大学学报(医学版)》2017年03期 　论文类型：期刊论文

【摘要】：目的探讨围孕期妇女服用叶酸与产儿先天性心脏病的关系,为采取有针对性的干预措施提供科学依据。方法应用分层随机整群抽样方法,抽取陕西省30个区县。对2010年1月至2013年11月间曾经怀孕、符合纳入标准、已知生育结局并知情同意的育龄妇女及其生育子女进行入户调查。采用Logistic回归模型控制相关影响因素分析妇女叶酸服用与产儿先天性心脏病发生的风险关系。结果本研究共纳入28 354名育龄妇女,其活产儿先天性心脏病患病率为7.3‰,育龄妇女围孕期叶酸服用率为64.4%,但其中按照规范服用叶酸的妇女仅占17.2%。围孕期妇女规范服用叶酸可能是产儿先天性心脏病的保护因素,单因素分析结果显示OR为0.502(95%CI:0.279~0.902);在控制了家庭背景因素,母亲因素以及孕期接触危险因素后多因素分析发现,叶酸规范服用仍然是先天性心脏病的保护性因素(调整OR=0.512,P=0.046)。然而,尚未发现不规范服用叶酸对产儿先天性心脏病发生的保护作用。结论按照规范时间和剂量服用叶酸(孕前3个月至孕早期3个月,每天服用0.4mg,且累计服用时间超过90d),可能预防先天性心脏病的发生。
[Abstract]:Objective to explore the relationship between folic acid use and congenital heart disease in infants during pregnancy, and to provide scientific basis for taking targeted intervention measures. Methods stratified random cluster sampling was used. Select 30 districts and counties in Shaanxi Province. For those who were pregnant between January 2010 and November 2013, they met the inclusion criteria. A household survey was conducted among women of childbearing age and their childbearing children who had known the outcome of birth and informed consent. The risk of congenital heart disease in infants was analyzed by using Logistic regression model to control the related influencing factors and to analyze the relationship between folic acid use in women and the incidence of congenital heart disease in infants. A total of 28,354 women of childbearing age were included in this study. The prevalence rate of congenital heart disease in live infants was 7.3 鈥，

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