可乐定透皮贴片治疗儿童中重度抽动障碍的临床研究

发布时间：2018-03-20 15:53

本文选题：可乐定透皮贴片　切入点：抽动障碍　出处：《中国当代儿科杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的观察可乐定透皮贴片与氟哌啶醇片治疗中重度儿童抽动障碍的疗效差异。方法将134例耶鲁大体抽动严重程度量表(YGTSS)总评分25分以上的中重度抽动障碍患儿随机分为可乐定组(70例)和氟哌啶醇组(64例)。可乐定组给予可乐定透皮贴片治疗,氟哌啶醇组给予氟哌啶醇治疗,疗程均为8周。采用YGTSS进行治疗前后症状评价,并记录治疗中的不良反应。结果氟哌啶醇组治疗1周的疗效高于可乐定组(P0.05);治疗后3周、5周、8周的疗效差异无统计学意义(P0.05)。在运动抽动积分、发声抽动积分、功能受损积分和总评分方面,治疗1周后可乐定组的YGTSS减分率均低于氟哌啶醇组(P0.05);治疗3周、5周、8周时,两组的YGTSS减分率差异无统计学意义(P0.05)。可乐定组总不良反应发生率为8%,低于氟哌啶醇组(37%)(P0.01)。结论可乐定透皮贴剂和氟哌啶醇均是治疗儿童中重度抽动障碍的有效药物,可乐定起效速度较慢,但疗效与氟哌啶醇相当,且不良反应低于氟哌啶醇。
[Abstract]:Objective to observe the difference of therapeutic effect between clonidine transdermal patch and haloperidol tablet in the treatment of moderate and severe children with tic disorder. Methods 134 children with moderate or severe tic disorder whose total score of Yale gross tic severity scale (YGTSS) was above 25 points were followed up. The machine was divided into clonidine group (n = 70) and haloperidol group (n = 64). Clonidine group was treated with clonidine transdermal patch. Haloperidol group was treated with haloperidol for 8 weeks. Symptoms were evaluated by YGTSS before and after treatment. Results the therapeutic effect of haloperidol group was higher than that of clonidine group for 1 week, but there was no significant difference in the effect between 3 weeks and 5 weeks after treatment. In terms of functional impairment score and total score, the YGTSS reduction rate in clonidine group was lower than that in haloperidol group after 1 week treatment, and at 3 weeks, 5 weeks and 8 weeks after treatment, the score reduction rate of clonidine group was lower than that of haloperidol group. There was no significant difference in YGTSS score reduction rate between the two groups (P 0.05). The incidence of total adverse reactions in clonidine group was 8, which was lower than that in haloperidol group. Conclusion clonidine transdermal patch and haloperidol are effective drugs for the treatment of moderate and severe tic disorder in children. Clonidine takes effect slowly, but the curative effect is equal to haloperidol, and the adverse reaction is lower than haloperidol.
【作者单位】：福建医科大学附属福建省妇幼保健院;
【分类号】：R749.94

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