血管迷走性晕厥儿童血清铁、血清铁蛋白的变化及临床意义

发布时间：2018-03-21 07:25

本文选题：血管迷走性晕厥　切入点：儿童　出处：《中南大学》2012年硕士论文　论文类型：学位论文

【摘要】：目的研究血管迷走性晕厥(VVS)儿童血清铁(SI)、血清铁蛋白(SF)的变化及临床意义,探讨其在儿童VVS发病机制中的作用。方法2011年5月～2012年4月在中南大学湘雅二医院儿童晕厥专科门诊就诊的不明原因晕厥(UPS)儿童,并经直立倾斜试验(HUTT)确诊为VVS的儿童21例为晕厥组,男12例,女9例,年龄8-14岁,平均(11.71±2.31)岁。选取性别、年龄匹配的18例健康儿童为对照组,男9例,女9例,年龄7～14岁,平均年龄(10.78±2.18)岁。对晕厥组儿童及对照组儿童在禁食禁饮12h后抽取肘静脉血分别测定血清铁(SI)、血清铁蛋白(SF)、血红蛋白(Hb)、血细胞比容(Hct)、平均红细胞体积(MCV)。将所得数据根据不同分类进行比较,用统计软件SPSS16.0进行数据统计分析。结果①一般资料比较：两组年龄(t=-1.32,P0.05)和性别(x2=0.199,P0.05)比较差异无统计学意义。②晕厥组与对照组比较,SI降低(15.15±4.55vs18.24±4.15μmol/L,P0.05).SF降低(59.10±26.81vs79.83±33.58μg/L,P0.05).Hct升高(40.19±3.44vs38.01±2.68%,P0.05)、MCV降低(84.85±5.80vs86.18±3.42fl,P0.05)、Hb降低(127.57±10.62vs132.29±12.57g/LP0.05)。③晕厥组不同性别SI、SF、Hct、MCV、Hb比较,男性稍高于女性(分别是15.34±3.26vs15.02±5.47μmol/L,P0.05:62.37±25.50vs54.76±29.42μg/L,P0.05；40.98±3.91vs39.14±2.50％,P0.05；85.47±4.60vs84.01±7.32fl,P0.05；134.67±13.49vs129.11±11.17g/L,P0.05).④反复晕厥组较偶发晕厥组SI、SF稍增高(15.19±4.37vs14.58±4.87μmol/L,P0.05:61.12±29.62vs57.27±25.30μg/L,P9.05),Hb.Hct.MCV稍降低(130.90±14.00vs133.55±11.65g/L,P0.05；40.12±3.73vs40.20±3.32％,p0.05；83.81±2.72vs85.99±7.98f1,P0.05). 结论①VVS儿童SI、SF显著低于对照组；②VVS儿童SI、SF性别之间差异无统计学意义。③SI、SF对估测VVS儿童晕厥频次无预测价值。
[Abstract]:Objective to study the changes and clinical significance of serum ferritin in children with vasovagal syncope (VVS) and to explore its role in the pathogenesis of VVS in children. Methods from May 2011 to April 2012, 21 children (12 males and 9 females) with VVS diagnosed by orthostatic tilt test in Xiangya second Hospital of Central South University were selected as syncope group. The age ranged from 8 to 14 years (mean 11.71 卤2.31) years. 18 healthy children with sex and matched age were selected as control group, including 9 males and 9 females, aged 7 to 14 years. The mean age was 10.78 卤2.18 years. The blood samples from elbow vein were collected from children in syncope group and control group after fasting for 12 hours. The blood samples were collected for the determination of serum iron siella, serum ferritin, hemoglobin hbtl, hematocrit, mean erythrocyte volume and MCV. Comparing them according to different classifications, Statistical software SPSS16.0 was used to analyze the data. Results 1 comparison of general data: there was no significant difference between the two groups in age and sex (P 0.05) and sex (20.199P0.05). 2 the SI of syncope group decreased 15.15 卤4.55 vs 18.24 卤4.15 渭 mol / L P 0.05. SF decreased 59.10 卤26.81 vs 79.83 卤33.58 渭 g / L P5 路ct increased 40.19 卤3.44vs38.01 卤2.68v / 0.05V decreased 84.85 卤5.80vs86.18 卤3.42flvs86.18 卤3.42flflg P0.05Hb decreased by 127.57 卤62v132.29 卤12.57g / L P0.05g / L P0.05g / L, compared with that of control group. It was slightly higher in males than in females (15.34 卤3.26vs15.02 卤5.47 渭 mol / L P0.0537 卤25.50vs54.76 卤29.42 渭 g / L P0.040.98 卤3.91vs39.14 卤2.50vs39.14 卤2.50vs0.055.47 卤4.60vs84.01 卤7.32flflP0.05134.67 卤13.49vs129.11 卤11.17g / L P0.055.4 vs 15.19 卤4.37vs14.58 卤4.87 渭 mol / L P0.058 卤4.87 渭 mol / L P0.053.73.73.73.73.83.92 卤4.87 渭 mol / g / L P < 0.05 卤627.27 卤25.30 渭 mol / L P9.05 卤13.534.67 卤13.49 vs 129.11 卤11.17g / L P 0.055.11 卤11.17g / L P0.055.73 卤0.053.73 卤0.053.73.73 卤0.053.73 卤0.053.73 卤0.053.73 卤0.053.73 卤0.053.73 卤0.053.73.73. Conclusion (1) there was no significant difference in Sisf between males and females in VVS children compared with the control group (2VVS). 3SI-SF had no predictive value in estimating the frequency of syncope in children with VVS.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R725.4

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