中药分期论治对咳嗽变异性哮喘患儿（虚寒证）血清IgE及ECP的影响

发布时间：2018-03-24 21:12

本文选题：咳嗽变异性哮喘　切入点：IgE　出处：《湖南中医药大学》2012年硕士论文

【摘要】：目的：观察咳嗽变异性哮喘(CVA)患儿经过分期治疗后血清免疫球蛋白E(IgE)和嗜酸性粒细胞阳离子蛋白(ECP)水平的变化,探讨IgE和ECP检测的临床意义,阐明中药治疗CVA的作用机理。方法：选取符合本研究标准的CVA(虚寒证)患儿60例(观察组),根据随机数字表法分为治疗组和对照组,每组30例。治疗组(中药组)发作期给予温肺化痰饮,缓解期给予补肺健脾饮；对照组(西药组)服用孟鲁司特钠,发作期加服氨茶碱治疗。另收取20例到我院体检的健康儿童做健康对照。观察组治疗前后均抽血测血清IgE及ECP,比较治疗前后这两种因子的变化情况,并分析和中药治疗的关系。结果：治疗前两组患儿的IgE和ECP水平与健康组比较差异有显著统计学意义(P0.01),治疗组和对照组比较二者差异无统计学意义(P0.05),具有可比性。治疗后治疗组IgE和ECP水平较治疗前差异有显著统计学意义(P0.01),对照组I gE水平较治疗前差异无统计学意义(P0.05),而ECP水平较治疗前差异有显著统计学意义(P0.01)。治疗后治疗组和健康组比较IgE无明显统计学意义(P0.05),而ECP差异有显著的统计学意义(P0.01)；治疗后对照组和健康组比较二者均有显著的统计学差异(P0.01)。受试对象治疗过程中,均无对药物过敏及病情恶化等不良反应。结论：IgE和ECP可能与CVA的发病有关,并且这两种因子对于指导CVA的诊断和治疗有一定的参考价值；中药能改善CVA患儿体内异常增高的IgE水平,作用优于对照组。
[Abstract]:Objective: to observe the changes of serum immunoglobulin (IgE) and eosinophil cationic protein (eep) levels in children with cough variant asthma (CVA) after treatment by stages, to explore the clinical significance of IgE and ECP detection and to elucidate the mechanism of traditional Chinese medicine in the treatment of CVA. Methods: 60 children with CVA (deficiency and cold syndrome) were randomly divided into treatment group and control group according to the method of random digital table. In the remission period, Bufei Jianpi decoction was given, while the control group (western medicine group) took montelukast sodium, Aminophylline was taken in the attack period, and 20 healthy children who came to our hospital for health control. Serum IgE and ECPwere measured before and after treatment in the observation group. The changes of these two factors were compared before and after treatment, and the relationship between the two factors and traditional Chinese medicine treatment was analyzed. Results: the levels of IgE and ECP in the two groups before treatment were significantly different from those in the healthy group (P 0.01), but there was no significant difference between the treatment group and the control group (P 0.05). The level of Ige in the control group was not significantly different from that before treatment, but the level of ECP was significantly higher than that before treatment. There was no significant difference in IgE between the treatment group and the healthy group after treatment. There was significant difference in ECP between control group and healthy group after treatment (P 0.01), and there was significant difference between control group and healthy group (P 0.01) during the course of treatment, and there was no significant difference between control group and healthy group in the course of treatment, and there was no significant difference between control group and healthy group in the course of treatment. There were no adverse reactions such as allergy to drugs and deterioration of the disease. ConclusionIgE and ECP may be related to the pathogenesis of CVA, and these two factors have certain reference value in guiding the diagnosis and treatment of CVA. Chinese herbal medicine can improve the abnormal increase of IgE level in children with CVA, and the effect is better than that in the control group.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R272

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