血清S100B蛋白和神经元特异性烯醇化酶预测手足口病严重程度的价值

发布时间：2018-03-25 14:05

本文选题：手足口病　切入点：SB蛋白　出处：《中国当代儿科杂志》2017年02期

【摘要】：目的探讨手足口病(HFMD)患儿血清S100B蛋白和神经元特异性烯醇化酶(NSE)水平检测对预测HFMD严重程度的价值。方法将90例HFMD患儿分为普通型、重型和危重型3组,每组30例;随机选取30例健康儿童作为对照组。ELISA法检测治疗前及治疗后7 d血清S100B蛋白和NSE水平。采用受试者操作特征曲线(ROC曲线)评价S100B蛋白和NSE对HFMD严重程度的预测效能。结果危重型HFMD患儿血清S100B蛋白和NSE水平均较其他3组明显升高(P0.01);重型患儿血清S100B蛋白和NSE水平均较普通型和对照组明显升高(P0.01)。与治疗前比较,危重型组和重型组治疗后血清S100B蛋白及NSE水平明显下降(P0.05)。当血清S100B蛋白在0.445μg/L时其Youden值最大,为0.611,其对重症HFMD(包括重型和危重型HFMD)预测的灵敏度为61%,特异度为100%。血清NSE在5.905μg/L时其Youden值最大,为0.533,其对重症HFMD预测的灵敏度为80%,特异度为73%。两个指标并联检测的灵敏度为86%,特异度为73%,对预测重症HFMD的价值最高。结论血清S100B蛋白和NSE有助于判断HFMD病情严重程度及治疗效果;二者如能并联检测对重症HFMD的预测价值更高。
[Abstract]:Objective to investigate the value of serum S100B protein and neuron-specific enolase (NSE) in predicting the severity of HFMD in children with HFMD. Serum S100B protein and NSE levels were measured by Elisa in 30 healthy children before and 7 days after treatment. The predictive effect of S100B protein and NSE on the severity of HFMD was evaluated by using the operating characteristic curve (ROC curve). Results the levels of serum S100B protein and NSE in children with severe HFMD were significantly higher than those in the other three groups, and the levels of serum S100B protein and NSE in severe children were significantly higher than those in the common type and control group. Compared with those before treatment, the levels of S100B protein and NSE in severe children were significantly higher than those in the control group. The levels of serum S100B protein and NSE decreased significantly in the critical and severe groups after treatment, and the Youden value was the highest when the serum S100B protein was at 0.445 渭 g / L. The sensitivity of predicting severe HFMD (including severe and critical HFMDs) was 61 and the specificity was 100. The Youden value of serum NSE at 5.905 渭 g / L was the highest. The sensitivity for predicting severe HFMD was 0. 533, and the specificity was 73. The sensitivity and specificity of the two indexes in parallel detection were 86 and 73, respectively. Conclusion Serum S100B protein and NSE are of the highest value in predicting severe HFMD. Conclusion Serum S100B protein and NSE are helpful to judge the severity of HFMD. Degree and therapeutic effect; If the two can be detected in parallel, the predictive value for severe HFMD is higher.
【作者单位】：青岛市妇女儿童医院儿童重症监护室;
【分类号】：R725.1

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