睾丸固定术对隐睾患儿血清抗苗勒管激素及抑制素B的影响研究

发布时间：2018-03-26 13:25

本文选题：睾丸固定术　切入点：抑制素B　出处：《中华男科学杂志》2017年08期

【摘要】：目的:研究单侧隐睾固定术前后血清抗苗勒管激素(AMH)及抑制素B(INHB)的变化。方法:选取单侧隐睾患儿58例行隐睾下降固定术(隐睾组),健康男性同龄儿童32例为对照组,在术前和术后6个月分别测量两组儿童阴茎长度、阴茎周径及隐睾侧睾丸体积,检测血清AMH及INHB水平。结果:隐睾组术前血清AMH(102.80±17.35)ng/ml、INHB(70.24±5.73)pg/ml与对照组血清AMH(108.76±13.64)ng/ml、INHB(77.72±5.94)pg/ml比较均明显下降,差异有统计学意义(P0.05);隐睾组术后6个月血清AMH(109.76±17.25)ng/ml、INHB(75.76±5.94)pg/ml与对照组血清AMH(108.03±14.13)ng/ml、INHB(77.63±5.99)pg/ml比较,均无显著性差异(P0.05);隐睾组术前阴茎长度(2.05±0.23)cm、阴茎周径(3.91±0.23)cm、隐睾侧睾丸体积(0.45±0.02)ml与对照组阴茎长度(2.11±0.22)cm、周径(3.99±0.20)cm、睾丸体积(0.46±0.02)ml比较,均无显著性差异(P0.05);隐睾组术后6个月阴茎长度(2.09±0.23)cm、阴茎周径(4.00±0.25)cm、隐睾侧睾丸体积(0.45±0.02)ml与对照组阴茎长度(2.16±0.22)cm、周径(3.98±0.19)cm、睾丸体积(0.45±0.02)ml比较,均无显著性差异(P0.05);隐睾组手术前、术后6个月血清AMH分别为(102.80±17.35、109.76±17.25)ng/ml、INHB分别为(70.24±5.73、75.76±5.94)pg/ml,两者比较差异有统计学意义(P0.05)。结论:血清AMH和INHB可用于评价睾丸固定术疗效,睾丸固定术能减少隐睾对睾丸功能的影响。
[Abstract]:Objective: to study the changes of serum anti-mullerian hormone (AMH) and inhibin INHBB before and after unilateral cryptorchidism fixation. Methods: 58 children with unilateral cryptorchidism were treated with descending fixation of cryptorchidism (cryptorchidism group, 32 healthy male children of the same age as control group). The length of penis, the circumference of penis and the volume of testis of cryptorchidism in both groups were measured before and 6 months after operation, and the serum AMH and INHB levels were measured. Results: the serum AMH(102.80 卤17.35 ng / ml AMH 70.24 卤5.73)pg/ml before operation in the cryptorchidism group was significantly lower than that in the control group (77.72 卤5.94)pg/ml). The difference was statistically significant (P 0.05), the serum AMH(109.76 卤17.25 ng / ml 5.94)pg/ml was 75.76 卤5.94)pg/ml 6 months after operation in the cryptorchidism group and the serum AMH(108.03 卤14.13 ng / ml 5.94)pg/ml in the control group was 77.63 卤5.99)pg/ml. In the cryptorchidism group, the penile length was 2.05 卤0.23 cm, the peripenile diameter was 3.91 卤0.23 cm, and the testicular volume of the cryptorchidism side was 0.45 卤0.22 cm, 2.11 卤0.22 cm, 3.99 卤0.20 cm and 0.46 卤0.02)ml, respectively. In the cryptorchidism group, there was no significant difference in penile length (2.09 卤0.23 cm), peripenile diameter (4.00 卤0.25) cm, testicular volume (0.45 卤0.02)ml) in the cryptorchidism group and the control group (2.16 卤0.22 cm, 3.98 卤0.19 cm, 0.45 卤0.45 卤0.02)ml), there was no significant difference in the length of the penis and the volume of the testis in the cryptorchidism group (P 0.05), and before the operation in the cryptorchidism group, there was no significant difference in the length of the penis between the cryptorchidism group and the control group (P < 0.05). Six months after operation, the serum AMH was 102.80 卤17.35109.76 卤17.25 ng / ml, respectively, and 70.24 卤5.73 卤5.94 ng / ml, respectively. The difference was statistically significant (P0.055.Conclusion: serum AMH and INHB can be used to evaluate the effect of testicular fixation, and testicular fixation can reduce the effect of cryptorchidism on testicular function.
【作者单位】：温州医科大学附属第二医院儿童内分泌遗传代谢科;温州医科大学附属第二医院生殖医学中心;温州医科大学附属第二医院泌尿外科;
【分类号】：R726.9

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