Fibrotest模型对胆道闭锁肝纤维化分级的诊断价值

发布时间：2018-03-26 17:34

本文选题：Fibrotest　切入点：胆道闭锁　出处：《广东医学》2017年03期

【摘要】：目的探讨Fibrotest模型对胆道闭锁肝纤维化分级的诊断价值。方法选择行肝脏病理检查的胆道闭锁患儿44例,收集术前1周内的患儿血清进行γ-谷氨酰转肽酶(GGT)、载脂蛋白A1(Apo A1)、总胆红素(TBi L)、α2-巨球蛋白(α2-MG)及结合珠蛋白(HAP)检测。以肝活检病理结果为金标准,将Fibrotest模型各检测指标及Fibrotest值与肝组织Metavir纤维化分级进行相关性分析,并进一步绘制Fibrotest值的ROC曲线。结果44例患儿肝活检结果显示F0期0例(0.0%)、F1期12例(27.3%)、F2期17例(38.6%)、F3期11例(25%)、F4期4例(9.1%),患儿血清的TBi L、GGT、Apo A1、α2-MG、HAP水平与肝纤维化分级均无明显相关性(r=-0.136、-0.040、0.042、0.100、-0.123,P0.05),同时,Fibrotest值与胆道闭锁患儿肝纤维化分级亦无明显相关性(r=0.008,P0.05)。Fibrotest模型诊断胆道闭锁肝脏纤维化分级的ROC曲线下面积为0.524(95%CI:0.307~0.693,P0.05)。结论 Fibrotest模型对胆道闭锁肝纤维化分级无明显诊断价值。
[Abstract]:Objective to investigate the diagnostic value of Fibrotest model in the classification of biliary atresia liver fibrosis. Methods 44 children with biliary atresia were selected for liver pathological examination. The serum samples of the children within 1 week before operation were collected for the detection of 纬 -glutamyl transpeptidase, apolipoprotein A1(Apo A _ 1, total bilirubin, 伪 _ 2-MGG, 伪 _ 2-MGG and bound globin HAP.The results of liver biopsy were used as the gold standard. The correlation analysis was made between the detection index and Fibrotest value of Fibrotest model and the Metavir fibrosis grade of liver tissue. The ROC curve of Fibrotest value was further drawn. Results the results of liver biopsy in 44 cases showed that there was no significant correlation between serum TBi LGGTApo A1, 伪 2-MGG HAP level and hepatic fibrosis grade in 12 cases of F _ 1 stage F _ 1 of F _ 0 stage and 17 cases of F _ 2 stage F _ 3 and F _ 3 stage F _ 3. There was no significant correlation between serum TBi LGGT Apo A1 and 伪 _ 2-MGG HAP level. There was no significant correlation between Fibrotest value and hepatic fibrosis grade in children with biliary atresia. The area under the ROC curve for diagnosis of hepatic fibrosis grade of biliary atresia was 0.524 95% CI 0.307i 0.693P0.050.Conclusion Fibrotest model has no obvious diagnostic value for hepatic fibrosis grade in children with biliary atresia.
【作者单位】：广州市妇女儿童医疗中心检验科;广州市妇女儿童医疗中心儿科研究所;广州市妇女儿童医疗中心病理科;
【基金】：广州市医药卫生科技一般引导项目(编号:20141A010025)
【分类号】：R726.5

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