上海市237名新生儿胎粪中邻苯二甲酸酯累积暴露的健康风险评估

发布时间：2018-03-27 11:37

  本文选题：邻苯二甲酸酯　切入点：新生儿　出处：《环境与职业医学》2017年05期

【摘要】：[目的]了解上海市新生儿接触邻苯二甲酸酯(PAEs)的暴露水平,并开展累积暴露的健康风险评估。[方法]对2013年7月—2014年7月于同济大学附属上海市第一妇幼保健院分娩的237名新生儿进行横断面观察,采用液相色谱串联质谱法(LC-MS/MS)检测胎粪中10种PAEs代谢物[邻苯二甲酸单甲酯(MMP)、邻苯二甲酸单乙酯(MEP)、邻苯二甲酸单正丁酯(MnBP)、邻苯二甲酸单异丁酯(MiBP)、邻苯二甲酸单苄基酯(MBzP)、邻苯二甲酸单(2-乙基己基)酯(MEHP)、单(2-乙基-5-氧代己基)邻苯二甲酸酯(MEOHP)、单(2-乙基-5-羧基戊基)邻苯二甲酸酯(MECPP)、单(2-乙基-5-羟基己基)邻苯二甲酸酯(MEHHP)、单(2-羧基己基)邻苯二甲酸酯(MCMHP)]的含量(质量分数,后同);并用胎粪中PAEs代谢物含量推算出6种PAEs[邻苯二甲酸二甲酯(DMP)、邻苯二甲酸二乙酯(DEP)、邻苯二甲酸二正丁酯(DnBP)、邻苯二甲酸二异丁酯(DiBP)和邻苯二甲酸丁基苄酯(BBP)、邻苯二甲酸二(2-乙基己基)酯(DEHP)]的每日估计暴露量(EDI);用危害指数(HI)法评估PAEs累积暴露的健康风险。[结果]新生儿胎粪中10种PAEs代谢物含量相对较高的为MEHP(65.00 ng/g)、MiBP(27.30 ng/g)和MnBP(27.90 ng/g),其检出率均超过90%。6种PAEs中,DiBP的EDI中位数为22.88μg/kg(以体重计),远高于DEP、DnBP、DMP、DEHP和BBP(中位数分别为3.45、2.96、1.90、1.19和0.41μg/kg)。237名新生儿中,HI≥1者有5名(2.11%),均为女婴。[结论]上海市237名新生儿中,有2.11%HI≥1,提示新生儿PAEs暴露的健康风险值得关注。
[Abstract]:[objective] to investigate the exposure level of newborn infants to PAEs in Shanghai. The health risk assessment of cumulative exposure was carried out. [methods] A cross-sectional observation of 237 newborns delivered in Shanghai first Maternal and Child Health Hospital affiliated to Tongji University from July 2013 to July 2014 was carried out. Determination of 10 PAEs metabolites in meconium by liquid chromatography-tandem mass spectrometry (LC-MS / MS): monomethyl phthalate (MMP), monoethyl phthalate (MMP), mono-butyl phthalate (n-butyl phthalate), monobenzyl phthalate (MBP), monobenzyl phthalate (MMP), monobutyl phthalate (MMP), monobutyl phthalate (MMP), monobenzyl phthalate (MMP). MEHPU, 2-ethylhexyl phthalate, 2-ethylhexyl phthalate, 2-ethyl-5-oxo-hexyl) phthalate, 2-ethyl-5-carboxypentyl) phthalate, mono2-ethyl-5-hydroxy-hexyl) phthalate, mono2-ethyl-5-hydroxy-hexyl) phthalate (MEHPU, 2-ethyl-5-hydroxy-hexyl) phthalate, mono-2-ethyl-5-hydroxyl) phthalate (MEHPU), mono-2-ethyl-5-carboxyamyl) phthalate (MEHPU), monoethyl-2-ethyl-5-hydroxy-hexyl) phthalate (MEHPU), mono-2-ethyl-5-carboxyl) phthalate (MEHPU). Content (mass fraction) of phthalate (MCMHP). Six kinds of PAEs (dimethyl phthalate, diethyl phthalate, dibutyl phthalate, dibutyl phthalate, diisobutyl phthalate, diisobutyl phthalate) and Ding Ji benzyl phthalate were calculated by using the content of PAEs metabolites in meconium. The estimated daily exposure of dimethylidene diethylhexyl phthalate (DEHP) and the health risk of cumulative exposure to PAEs were evaluated by hazard index method. [results] the 10 metabolites of PAEs in neonatal meconium were relatively high in MEHP(65.00 ng / gr ~ (-1) and MnBP(27.90 (27.30 ng / g). The detection rate of PAEs was above 90. 6 渭 g / kg. The median EDI of DiBP was 22.88 渭 g / kg (in body weight, it was much higher than DEHP and BBP (the median was 3.452.91.91.901.19 and 0.41 渭 g/kg).237). There were 5 female infants with HI 鈮，

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