妊娠期抑郁症与新生儿低出生体重关系的Meta分析

发布时间：2018-03-27 13:43

本文选题：妊娠期抑郁症　切入点：低出生体重　出处：《中国当代儿科杂志》2017年09期

【摘要】：目的探讨妊娠期抑郁症与新生儿低出生体重的关系,为预防新生儿低出生体重提供科学依据。方法系统收集研究妊娠期抑郁症与低出生体重关系的队列研究文献,进行Meta分析,由两名研究人员独立地提取数据,按照NOS量表对纳入文献进行质量评价,采用Egger's检验评估发表偏倚。结果共纳入12篇队列研究文献,涉及37 192个样本。Meta分析结果表明:妊娠期抑郁症与新生儿低出生体重有关(Z=2.08,P=0.038),妊娠期抑郁的孕母其新生儿发生低出生体重的风险更高(RR=1.303,95%CI:1.015~1.672)。敏感性分析结果表明该Meta分析结果稳定可靠,Egger's检验结果表明无发表偏倚。结论妊娠期抑郁症可能是新生儿低出生体重的危险因素。
[Abstract]:Objective to explore the relationship between depression in pregnancy and low birth weight of newborn, and to provide scientific basis for prevention of low birth weight of newborn. Methods A cohort study on the relationship between depression in pregnancy and low birth weight was systematically collected and analyzed by Meta. The data were extracted by two researchers independently, and the quality of the literature was evaluated according to the NOS scale, and the bias of publication was evaluated by Egger's test. The results were included in 12 cohort studies. The results of meta-analysis showed that depression in pregnancy was associated with low birth weight of newborn infants. The risk of low birth weight in pregnant mothers with depression during pregnancy was higher than that in newborns with low birth weight. Sensitivity analysis showed that the Meta score was higher than that of pregnant mothers with low birth weight. Conclusion pregnancy depression may be a risk factor for low birth weight of newborns.
【作者单位】：徐州医科大学公共卫生学院;新乡医学院基础医学院;徐州医科大学护理学院;
【基金】：江苏高校哲学社会科学研究一般项目(2015SJB414)
【分类号】：R722.1

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