穴位埋线联合孟鲁司特钠对小儿咳嗽变异性哮喘疗效及免疫功能的影响

发布时间：2018-03-28 04:31

本文选题：变异性哮喘　切入点：穴位埋线　出处：《山东医药》2017年13期

【摘要】：目的探讨穴位埋线联合孟鲁司特钠治疗小儿咳嗽变异性哮喘(CVA)的疗效及对患儿免疫功能的影响。方法 CVA患儿96例,根据随机数字表法将患儿分为观察组与对照组各48例。两组均采用孟鲁司特钠咀嚼片治疗,每晚睡前服用1次;观察组在对照组基础上加用穴位埋线,采取缝合针沿着穴位肌肉层或皮下组织横向埋入无菌00号羊肠线,15 d后再次埋线,第2~3个月,每月埋线1次,3个月共埋线4次,两组均连续治疗3个月。观察临床疗效,检测T淋巴细胞亚群及血清免疫球蛋白。并随访1年,观察咳嗽缓解时间、咳嗽消失时间,统计停药6个月、1年时的复发率。结果观察组总有效率为95.83%,对照组为81.25%,两组比较,P0.05;两组治疗后、随访1年时咳嗽缓解时间、咳嗽消失时间均较治疗前缩短(P均0.01),以观察组为著(P均0.01);观察组停药6个月、1年时复发率分别为0、4.17%,低于对照组的8.33%、16.67%(P均0.05);治疗3个月两组血清Ig A、Ig G、Ig M水平均上升(P均0.01),Ig E水平下降,以观察组为著(P0.01);治疗3个月两组CD3+、CD4+T细胞百分比、CD4+/CD8+均上升,CD8+T细胞百分比下降,以观察组为著(P均0.01)。结论穴位埋线联合孟鲁司特钠治疗小儿CVA相对于单用孟鲁司特钠治疗可有效提高近期及远期疗效,缓解咳嗽症状,提高机体免疫功能。
[Abstract]:Objective to investigate the effect of acupoint catgut embedding combined with montelukast sodium on children with cough variant asthma (CVA) and its effect on immune function. According to the method of random number table, the children were divided into the observation group (n = 48) and the control group (n = 48). Both groups were treated with montelukast sodium chewable tablet once a night before going to bed. The suture needle was used to insert aseptic No. 00 suture into the muscle layer or subcutaneous tissue of the acupoint for 15 days, and then buried again in the 2nd ~ 3rd month, once a month, 4 times in 3 months. The two groups were treated continuously for 3 months. The clinical curative effect was observed. T-lymphocyte subsets and serum immunoglobulin were detected and followed up for 1 year to observe the time of cough relief and the time of cough disappearance. Results the total effective rate of observation group was 95.83 and that of control group was 81.255.Results the total effective rate was 95.83 in the observation group and 81.25 in the control group (P 0.05). The time of cough disappearance was shorter than that before treatment (P < 0.01), and that of observation group was 0.01g, the relapse rate of observation group was 0 ~ 4.17 at 1 year, which was lower than that of control group (8.33 ~ 16.67) P 0.05, and the level of serum Ig IgG was increased in two groups after 3 months of treatment, and the recurrence rate of treatment group was 0 ~ (4.17) at 1 year, which was lower than that of control group (8.33 ~ 16.67%, P < 0.05), and the level of serum Ig IgG in two groups increased after 3 months. The levels of Ig E were decreased in both 0. 01% and 0. 01% of P, respectively. In the observation group, the percentage of CD4 / CD8 of CD3 T cells increased and the percentage of CD8 T cells decreased after 3 months of treatment, while in the observation group, the percentage of CD4 / CD8 increased, and the percentage of CD4 / CD8 increased in both groups after 3 months of treatment. Conclusion compared with montelukast sodium alone, acupoint catgut implantation combined with montelukast sodium can effectively improve the short-term and long-term effects, relieve cough symptoms and improve the immune function of children with CVA compared with montelukast alone.
【作者单位】：华北理工大学医院;唐山市第四医院;
【基金】：河北省中医药管理局科研计划项目(2016195)
【分类号】：R725.6

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